Frizzled-4
Intramolecular
Cysteine 181 and cysteine 200
Cysteine 45 and cysteine 106
Cysteine 121 and cysteine 145
Cysteine 53 and cysteine 99
Cysteine 90 and cysteine 128
Cysteine 302 and cysteine 377
Cysteine 117 and cysteine 158
Cysteine 204 and cysteine 282
Cysteine 1039 and cysteine 377
Cysteine 53 and cysteine 377
More...Cysteine 261 and cysteine 377
Cysteine 53 and cysteine 261
Cysteine 204 and cysteine 377
Cysteine 117 and cysteine 121
Cysteine 282 and cysteine 377
Cysteine 261 and cysteine 1039
Cysteine 53 and cysteine 1039
6bd4 A 181 A 200
A redox-regulated disulphide may form within Frizzled-4 between cysteines 181 and 200.
Details
Redox score ?
90
PDB code
6bd4
Structure name
crystal structure of human apo-frizzled4 receptor
Structure deposition date
2017-10-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9ULV1
Residue number A
181
Residue number B
200
Peptide name
Frizzled-4
Ligandability
Cysteine 181 of Frizzled-4
Cysteine 200 of Frizzled-4
5bqe C 45 C 106
A redox-regulated disulphide may form within Frizzled-4 between cysteines 45 and 106.
Details
Redox score ?
86
PDB code
5bqe
Structure name
crystal structure of norrin in complex with the cysteine-rich domain of frizzled 4 -methylated form
Structure deposition date
2015-05-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9ULV1
Residue number A
45
Residue number B
106
Peptide name
Frizzled-4
Ligandability
Cysteine 45 of Frizzled-4
Cysteine 106 of Frizzled-4
5cl1 D 121 D 145
A redox-regulated disulphide may form within Frizzled-4 between cysteines 121 and 145.
Details
Redox score ?
85
PDB code
5cl1
Structure name
complex structure of norrin with human frizzled 4
Structure deposition date
2015-07-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9ULV1
Residue number A
121
Residue number B
145
Peptide name
Frizzled-4
Ligandability
Cysteine 121 of Frizzled-4
Cysteine 145 of Frizzled-4
5bpq C 53 C 99
A redox-regulated disulphide may form within Frizzled-4 between cysteines 53 and 99.
Details
Redox score ?
84
PDB code
5bpq
Structure name
crystal structure of the cysteine-rich domain of human frizzled 4 - crystal form ii
Structure deposition date
2015-05-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9ULV1
Residue number A
53
Residue number B
99
Peptide name
Frizzled-4
Ligandability
Cysteine 53 of Frizzled-4
Cysteine 99 of Frizzled-4
5bpq D 90 D 128
A redox-regulated disulphide may form within Frizzled-4 between cysteines 90 and 128.
Details
Redox score ?
84
PDB code
5bpq
Structure name
crystal structure of the cysteine-rich domain of human frizzled 4 - crystal form ii
Structure deposition date
2015-05-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9ULV1
Residue number A
90
Residue number B
128
Peptide name
Frizzled-4
Ligandability
Cysteine 90 of Frizzled-4
Cysteine 128 of Frizzled-4
6bd4 A 302 A 377
A redox-regulated disulphide may form within Frizzled-4 between cysteines 302 and 377.
Details
Redox score ?
82
PDB code
6bd4
Structure name
crystal structure of human apo-frizzled4 receptor
Structure deposition date
2017-10-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9ULV1
Residue number A
302
Residue number B
377
Peptide name
Frizzled-4
Ligandability
Cysteine 302 of Frizzled-4
Cysteine 377 of Frizzled-4
5bqc B 117 B 158
A redox-regulated disulphide may form within Frizzled-4 between cysteines 117 and 158.
Details
Redox score ?
80
PDB code
5bqc
Structure name
crystal structure of norrin in complex with the cysteine-rich domain of frizzled 4 and sucrose octasulfate
Structure deposition date
2015-05-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9ULV1
Residue number A
117
Residue number B
158
Peptide name
Frizzled-4
Ligandability
Cysteine 117 of Frizzled-4
Cysteine 158 of Frizzled-4
6bd4 A 204 A 282
A redox-regulated disulphide may form within Frizzled-4 between cysteines 204 and 282.
Details
Redox score ?
80
PDB code
6bd4
Structure name
crystal structure of human apo-frizzled4 receptor
Structure deposition date
2017-10-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9ULV1
Residue number A
204
Residue number B
282
Peptide name
Frizzled-4
Ligandability
Cysteine 204 of Frizzled-4
Cysteine 282 of Frizzled-4
6bd4 A 1039 A 1042
A redox-regulated disulphide may form within Frizzled-4 between cysteines 1039 and 377 (1039 and 1042 respectively in this structure).
Details
Redox score ?
75
PDB code
6bd4
Structure name
crystal structure of human apo-frizzled4 receptor
Structure deposition date
2017-10-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9ULV1
Residue number A
1039
Residue number B
377
Peptide name
Frizzled-4
Ligandability
Cysteine 1039 of Frizzled-4
Cysteine 377 of Frizzled-4
Cysteine 1039 in protein A could not be asigned to a Uniprot residue.
6bd4 A 1006 A 1042
A redox-regulated disulphide may form within Frizzled-4 between cysteines 53 and 377 (1006 and 1042 respectively in this structure).
Details
Redox score ?
75
PDB code
6bd4
Structure name
crystal structure of human apo-frizzled4 receptor
Structure deposition date
2017-10-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
42
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9ULV1
Residue number A
53
Residue number B
377
Peptide name
Frizzled-4
Ligandability
Cysteine 53 of Frizzled-4
Cysteine 377 of Frizzled-4
6bd4 A 1009 A 1042
A redox-regulated disulphide may form within Frizzled-4 between cysteines 261 and 377 (1009 and 1042 respectively in this structure).
Details
Redox score ?
75
PDB code
6bd4
Structure name
crystal structure of human apo-frizzled4 receptor
Structure deposition date
2017-10-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
33
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9ULV1
Residue number A
261
Residue number B
377
Peptide name
Frizzled-4
Ligandability
Cysteine 261 of Frizzled-4
Cysteine 377 of Frizzled-4
6bd4 A 1006 A 1009
A redox-regulated disulphide may form within Frizzled-4 between cysteines 53 and 261 (1006 and 1009 respectively in this structure).
Details
Redox score ?
74
PDB code
6bd4
Structure name
crystal structure of human apo-frizzled4 receptor
Structure deposition date
2017-10-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9ULV1
Residue number A
53
Residue number B
261
Peptide name
Frizzled-4
Ligandability
Cysteine 53 of Frizzled-4
Cysteine 261 of Frizzled-4
6bd4 A 204 A 377
A redox-regulated disulphide may form within Frizzled-4 between cysteines 204 and 377. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
6bd4
Structure name
crystal structure of human apo-frizzled4 receptor
Structure deposition date
2017-10-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9ULV1
Residue number A
204
Residue number B
377
Peptide name
Frizzled-4
Ligandability
Cysteine 204 of Frizzled-4
Cysteine 377 of Frizzled-4
5bqc B 117 B 121
A redox-regulated disulphide may form within Frizzled-4 between cysteines 117 and 121. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
5bqc
Structure name
crystal structure of norrin in complex with the cysteine-rich domain of frizzled 4 and sucrose octasulfate
Structure deposition date
2015-05-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9ULV1
Residue number A
117
Residue number B
121
Peptide name
Frizzled-4
Ligandability
Cysteine 117 of Frizzled-4
Cysteine 121 of Frizzled-4
6bd4 A 282 A 377
A redox-regulated disulphide may form within Frizzled-4 between cysteines 282 and 377. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
6bd4
Structure name
crystal structure of human apo-frizzled4 receptor
Structure deposition date
2017-10-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9ULV1
Residue number A
282
Residue number B
377
Peptide name
Frizzled-4
Ligandability
Cysteine 282 of Frizzled-4
Cysteine 377 of Frizzled-4
6bd4 A 1009 A 1039
A redox-regulated disulphide may form within Frizzled-4 between cysteines 261 and 1039 (1009 and 1039 respectively in this structure).
Details
Redox score ?
nan
PDB code
6bd4
Structure name
crystal structure of human apo-frizzled4 receptor
Structure deposition date
2017-10-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9ULV1
Residue number A
261
Residue number B
1039
Peptide name
Frizzled-4
Ligandability
Cysteine 261 of Frizzled-4
Cysteine 1039 of Frizzled-4
Cysteine 1039 in protein B could not be asigned to a Uniprot residue.
6bd4 A 1006 A 1039
A redox-regulated disulphide may form within Frizzled-4 between cysteines 53 and 1039 (1006 and 1039 respectively in this structure).
Details
Redox score ?
nan
PDB code
6bd4
Structure name
crystal structure of human apo-frizzled4 receptor
Structure deposition date
2017-10-21
Thiol separation (Å)
5
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9ULV1
Residue number A
53
Residue number B
1039
Peptide name
Frizzled-4
Ligandability
Cysteine 53 of Frizzled-4
Cysteine 1039 of Frizzled-4
Cysteine 1039 in protein B could not be asigned to a Uniprot residue.
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