ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cip1-interacting zinc finger protein

Intramolecular
Cysteine 739 and cysteine 595
Cysteine 739 and cysteine 33
A redox-regulated disulphide may form within Cip1-interacting zinc finger protein between cysteines 739 and 595 (28 and 69 respectively in this structure).

Details

Redox score ?
68
PDB code
7x39
Structure name
structure of ciz1 bound erh
Structure deposition date
2022-02-28
Thiol separation (Å)
5
Half-sphere exposure sum ?
70
Minimum pKa ?
8
% buried
74
Peptide accession
Q9ULV3
Residue number A
739
Residue number B
595
Peptide name
Cip1-interacting zinc finger protein

Ligandability

Cysteine 739 of Cip1-interacting zinc finger protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 595 of Cip1-interacting zinc finger protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Uncertain whether structure cysteine 28 has been assigned to correct residue.
A redox-regulated disulphide may form within Cip1-interacting zinc finger protein between cysteines 739 and 33 (28 and 33 respectively in this structure).

Details

Redox score ?
nan
PDB code
7x39
Structure name
structure of ciz1 bound erh
Structure deposition date
2022-02-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
12
% buried
86
Peptide accession
Q9ULV3
Residue number A
739
Residue number B
33
Peptide name
Cip1-interacting zinc finger protein

Ligandability

Cysteine 739 of Cip1-interacting zinc finger protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 33 of Cip1-interacting zinc finger protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Uncertain whether structure cysteine 28 has been assigned to correct residue.
Cysteine 33 in protein B could not be asigned to a Uniprot residue.
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