ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Coronin-1C

Intramolecular
Cysteine 39 and cysteine 343
Cysteine 23 and cysteine 343
Cysteine 103 and cysteine 151
A redox-regulated disulphide may form within Coronin-1C between cysteines 39 and 343.

Details

Redox score ?
64
PDB code
7sty
Structure name
crystal structure of human coro1c
Structure deposition date
2021-11-15
Thiol separation (Å)
5
Half-sphere exposure sum ?
92
Minimum pKa ?
9
% buried
100
Peptide accession
Q9ULV4
Residue number A
39
Residue number B
343
Peptide name
Coronin-1C

Ligandability

Cysteine 39 of Coronin-1C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 343 of Coronin-1C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Coronin-1C between cysteines 23 and 343. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7sty
Structure name
crystal structure of human coro1c
Structure deposition date
2021-11-15
Thiol separation (Å)
8
Half-sphere exposure sum ?
78
Minimum pKa ?
11
% buried
71
Peptide accession
Q9ULV4
Residue number A
23
Residue number B
343
Peptide name
Coronin-1C

Ligandability

Cysteine 23 of Coronin-1C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 343 of Coronin-1C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Coronin-1C between cysteines 103 and 151. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7sty
Structure name
crystal structure of human coro1c
Structure deposition date
2021-11-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
26
Peptide accession
Q9ULV4
Residue number A
103
Residue number B
151
Peptide name
Coronin-1C

Ligandability

Cysteine 103 of Coronin-1C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 151 of Coronin-1C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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