ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Frizzled-10

Intramolecular
Cysteine 34 and cysteine 95
Cysteine 79 and cysteine 117
Cysteine 110 and cysteine 134
Cysteine 42 and cysteine 88
Cysteine 106 and cysteine 147
A redox-regulated disulphide may form within Frizzled-10 between cysteines 34 and 95.

Details

Redox score ?
88
PDB code
7x8t
Structure name
frizzled 10 crd in complex with hb9l9
Structure deposition date
2022-03-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9ULW2
Residue number A
34
Residue number B
95
Peptide name
Frizzled-10

Ligandability

Cysteine 34 of Frizzled-10

Cysteine 95 of Frizzled-10

A redox-regulated disulphide may form within Frizzled-10 between cysteines 79 and 117.

Details

Redox score ?
87
PDB code
7x8t
Structure name
frizzled 10 crd in complex with hb9l9
Structure deposition date
2022-03-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9ULW2
Residue number A
79
Residue number B
117
Peptide name
Frizzled-10

Ligandability

Cysteine 79 of Frizzled-10

Cysteine 117 of Frizzled-10

A redox-regulated disulphide may form within Frizzled-10 between cysteines 110 and 134.

Details

Redox score ?
85
PDB code
7x8q
Structure name
frizzled-10 crd in complex with f10_a9 fab
Structure deposition date
2022-03-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9ULW2
Residue number A
110
Residue number B
134
Peptide name
Frizzled-10

Ligandability

Cysteine 110 of Frizzled-10

Cysteine 134 of Frizzled-10

A redox-regulated disulphide may form within Frizzled-10 between cysteines 42 and 88.

Details

Redox score ?
83
PDB code
7x8t
Structure name
frizzled 10 crd in complex with hb9l9
Structure deposition date
2022-03-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9ULW2
Residue number A
42
Residue number B
88
Peptide name
Frizzled-10

Ligandability

Cysteine 42 of Frizzled-10

Cysteine 88 of Frizzled-10

A redox-regulated disulphide may form within Frizzled-10 between cysteines 106 and 147.

Details

Redox score ?
81
PDB code
7x8t
Structure name
frizzled 10 crd in complex with hb9l9
Structure deposition date
2022-03-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9ULW2
Residue number A
106
Residue number B
147
Peptide name
Frizzled-10

Ligandability

Cysteine 106 of Frizzled-10

Cysteine 147 of Frizzled-10

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