RNA-binding protein NOB1
Intramolecular
Cysteine 270 and cysteine 273
Cysteine 285 and cysteine 288 L
Cysteine 270 and cysteine 285 L
Cysteine 273 and cysteine 285 L
Cysteine 273 and cysteine 288
Cysteine 270 and cysteine 288
7wu0 y 270 y 273
A redox-regulated disulphide may form within RNA-binding protein NOB1 between cysteines 270 and 273.
Details
Redox score ?
86
PDB code
7wu0
Structure name
cryo-em structure of a human pre-40s ribosomal subunit - state rrp12- b3
Structure deposition date
2022-02-05
Thiol separation (Å)
3
Half-sphere exposure sum ?
72
Minimum pKa ?
4
% buried
94
Peptide accession
Q9ULX3
Residue number A
270
Residue number B
273
Peptide name
RNA-binding protein NOB1
Ligandability
Cysteine 270 of RNA-binding protein NOB1
Cysteine 273 of RNA-binding protein NOB1
7wtz y 285 y 288
A redox-regulated disulphide may form within RNA-binding protein NOB1 between cysteines 285 and 288.
Details
Redox score ?
81
PDB code
7wtz
Structure name
cryo-em structure of a human pre-40s ribosomal subunit - state rrp12- b2
Structure deposition date
2022-02-05
Thiol separation (Å)
3
Half-sphere exposure sum ?
76
Minimum pKa ?
4
% buried
94
Peptide accession
Q9ULX3
Residue number A
285
Residue number B
288
Peptide name
RNA-binding protein NOB1
Ligandability
Cysteine 285 of RNA-binding protein NOB1
Cysteine 288 of RNA-binding protein NOB1
7wu0 y 270 y 285
A redox-regulated disulphide may form within RNA-binding protein NOB1 between cysteines 270 and 285.
Details
Redox score ?
79
PDB code
7wu0
Structure name
cryo-em structure of a human pre-40s ribosomal subunit - state rrp12- b3
Structure deposition date
2022-02-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
4
% buried
90
Peptide accession
Q9ULX3
Residue number A
270
Residue number B
285
Peptide name
RNA-binding protein NOB1
Ligandability
Cysteine 270 of RNA-binding protein NOB1
Cysteine 285 of RNA-binding protein NOB1
7wtx y 273 y 285
A redox-regulated disulphide may form within RNA-binding protein NOB1 between cysteines 273 and 285.
Details
Redox score ?
79
PDB code
7wtx
Structure name
cryo-em structure of a human pre-40s ribosomal subunit - state rrp12- b1
Structure deposition date
2022-02-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
5
% buried
92
Peptide accession
Q9ULX3
Residue number A
273
Residue number B
285
Peptide name
RNA-binding protein NOB1
Ligandability
Cysteine 273 of RNA-binding protein NOB1
Cysteine 285 of RNA-binding protein NOB1
6g5i y 273 y 288
A redox-regulated disulphide may form within RNA-binding protein NOB1 between cysteines 273 and 288. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
6g5i
Structure name
cryo-em structure of a late human pre-40s ribosomal subunit - state r
Structure deposition date
2018-03-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
82
Minimum pKa ?
19
% buried
nan
Peptide accession
Q9ULX3
Residue number A
273
Residue number B
288
Peptide name
RNA-binding protein NOB1
Ligandability
Cysteine 273 of RNA-binding protein NOB1
Cysteine 288 of RNA-binding protein NOB1
7wtx y 270 y 288
A redox-regulated disulphide may form within RNA-binding protein NOB1 between cysteines 270 and 288. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7wtx
Structure name
cryo-em structure of a human pre-40s ribosomal subunit - state rrp12- b1
Structure deposition date
2022-02-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
24
% buried
nan
Peptide accession
Q9ULX3
Residue number A
270
Residue number B
288
Peptide name
RNA-binding protein NOB1
Ligandability
Cysteine 270 of RNA-binding protein NOB1
Cysteine 288 of RNA-binding protein NOB1
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