a tool for identifying drug-targetable redox-active disulphides

Carbonic anhydrase 14

Intramolecular

Cysteine 40 and cysteine 221

A redox-regulated disulphide may form within Carbonic anhydrase 14 between cysteines 40 and 221 (23 and 203 respectively in this structure).

Details

Redox score ?

86

PDB code

Structure name

the crystal structure of the human carbonic anhydrase xiv

Structure deposition date

2013-07-24

Thiol separation (Å)

2

Half-sphere exposure sum ?

64

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

40

Residue number B

221

Peptide name

Carbonic anhydrase 14

Ligandability

Cysteine 40 of Carbonic anhydrase 14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 221 of Carbonic anhydrase 14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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