ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Fizzy-related protein homolog

Intramolecular
Cysteine 381 and cysteine 395
Cysteine 208 and cysteine 223
A redox-regulated disulphide may form within Fizzy-related protein homolog between cysteines 381 and 395. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
4ui9
Structure name
atomic structure of the human anaphase-promoting complex
Structure deposition date
2015-03-27
Thiol separation (Å)
7
Half-sphere exposure sum ?
61
Minimum pKa ?
9
% buried
30
Peptide accession
Q9UM11
Residue number A
381
Residue number B
395
Peptide name
Fizzy-related protein homolog

Ligandability

Cysteine 381 of Fizzy-related protein homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 395 of Fizzy-related protein homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fizzy-related protein homolog between cysteines 208 and 223. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7qe7
Structure name
high-resolution structure of the anaphase-promoting complex/cyclosome (apc/c) bound to co-activator cdh1
Structure deposition date
2021-12-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
34
Peptide accession
Q9UM11
Residue number A
208
Residue number B
223
Peptide name
Fizzy-related protein homolog

Ligandability

Cysteine 208 of Fizzy-related protein homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 223 of Fizzy-related protein homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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