a tool for identifying drug-targetable redox-active disulphides

Anaphase-promoting complex subunit 10

Intermolecular

Cysteine 36 and cysteine 1288 of Anaphase-promoting complex subunit 1

A redox-regulated disulphide may form between cysteine 36 of Anaphase-promoting complex subunit 10 and cysteine 1288 of Anaphase-promoting complex subunit 1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

55

PDB code

Structure name

high-resolution structure of the anaphase-promoting complex/cyclosome (apc/c) bound to co-activator cdh1

Structure deposition date

2021-12-01

Thiol separation (Å)

7

Half-sphere exposure sum ?

63

Minimum pK_a ?

10

% buried

64

Peptide A name

Anaphase-promoting complex subunit 10

Peptide B name

Anaphase-promoting complex subunit 1

Peptide A accession

Peptide B accession

Peptide A residue number

36

Peptide B residue number

1288

Ligandability

Cysteine 36 of Anaphase-promoting complex subunit 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1288 of Anaphase-promoting complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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