Neurogenic locus notch homolog protein 3

Peptide B accession

Peptide A residue number

1484

Peptide B residue number

1484

Ligandability

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form between two units of Neurogenic locus notch homolog protein 3 at cysteines 1500 and 1484 (1501 and 1485 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

6xsw

Structure name

structure of the notch3 nrr in complex with an antibody fab fragment

Structure deposition date

2020-07-16

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide A name

Neurogenic locus notch homolog protein 3

Peptide B name

Neurogenic locus notch homolog protein 3

Peptide A accession

Peptide B accession

Peptide A residue number

1500

Peptide B residue number

1484

Ligandability

Cysteine 1500 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

Cysteine 1484 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form between two units of Neurogenic locus notch homolog protein 3 at cysteines 1488 and 1488. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

4zlp

Structure name

crystal structure of notch3 negative regulatory region

Structure deposition date

2015-05-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide A name

Neurogenic locus notch homolog protein 3

Peptide B name

Neurogenic locus notch homolog protein 3

Peptide A accession

Peptide B accession

Peptide A residue number

1488

Peptide B residue number

1488

Ligandability

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form between two units of Neurogenic locus notch homolog protein 3 at cysteines 1500 and 1500 (1501 and 1501 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

6xsw

Structure name

structure of the notch3 nrr in complex with an antibody fab fragment

Structure deposition date

2020-07-16

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide A name

Neurogenic locus notch homolog protein 3

Peptide B name

Neurogenic locus notch homolog protein 3

Peptide A accession

Peptide B accession

Peptide A residue number

1500

Peptide B residue number

1500

Ligandability

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form between two units of Neurogenic locus notch homolog protein 3 at cysteines 1475 and 1488. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

4zlp

Structure name

crystal structure of notch3 negative regulatory region

Structure deposition date

2015-05-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide A name

Neurogenic locus notch homolog protein 3

Peptide B name

Neurogenic locus notch homolog protein 3

Peptide A accession

Peptide B accession

Peptide A residue number

1475

Peptide B residue number

1488

Ligandability

Cysteine 1475 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

Cysteine 1488 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Neurogenic locus notch homolog protein 3 between cysteines 1387 and 1410.

Details

Redox score ?

PDB code

Structure name

crystal structure of notch3 nrr in complex with 20358 fab

Structure deposition date

2015-08-01

Thiol separation (Å)

Half-sphere exposure sum ?

nan

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

1387

Residue number B

1410

Peptide name

Neurogenic locus notch homolog protein 3

Ligandability

Cysteine 1387 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

Cysteine 1410 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Neurogenic locus notch homolog protein 3 between cysteines 1392 and 1405.

Details

Redox score ?

PDB code

Structure name

crystal structure of notch3 nrr in complex with 20358 fab

Structure deposition date

2015-08-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

1392

Residue number B

1405

Peptide name

Neurogenic locus notch homolog protein 3

Ligandability

Cysteine 1392 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

Cysteine 1405 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Neurogenic locus notch homolog protein 3 between cysteines 1428 and 1451.

Details

Redox score ?

PDB code

Structure name

crystal structure of notch3 nrr in complex with 20358 fab

Structure deposition date

2015-08-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

1428

Residue number B

1451

Peptide name

Neurogenic locus notch homolog protein 3

Ligandability

Cysteine 1428 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

Cysteine 1451 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Neurogenic locus notch homolog protein 3 between cysteines 1433 and 1446.

Details

Redox score ?

PDB code

Structure name

crystal structure of notch3 nrr in complex with 20358 fab

Structure deposition date

2015-08-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

1433

Residue number B

1446

Peptide name

Neurogenic locus notch homolog protein 3

Ligandability

Cysteine 1433 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

Cysteine 1446 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Neurogenic locus notch homolog protein 3 between cysteines 1591 and 1600.

Details

Redox score ?

PDB code

Structure name

crystal structure of notch3 nrr in complex with 20358 fab

Structure deposition date

2015-08-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

1591

Residue number B

1600

Peptide name

Neurogenic locus notch homolog protein 3

Ligandability

Cysteine 1591 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

Cysteine 1600 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Neurogenic locus notch homolog protein 3 between cysteines 1442 and 1458.

Details

Redox score ?

PDB code

Structure name

crystal structure of notch3 nrr in complex with 20358 fab

Structure deposition date

2015-08-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

1442

Residue number B

1458

Peptide name

Neurogenic locus notch homolog protein 3

Ligandability

Cysteine 1442 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

Cysteine 1458 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Neurogenic locus notch homolog protein 3 between cysteines 1467 and 1493.

Details

Redox score ?

PDB code

Structure name

crystal structure of notch3 nrr in complex with 20358 fab

Structure deposition date

2015-08-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

1467

Residue number B

1493

Peptide name

Neurogenic locus notch homolog protein 3

Ligandability

Cysteine 1467 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

Cysteine 1493 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Neurogenic locus notch homolog protein 3 between cysteines 1428 and 1433.

Details

Redox score ?

PDB code

Structure name

crystal structure of notch3 nrr in complex with 20358 fab

Structure deposition date

2015-08-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

1428

Residue number B

1433

Peptide name

Neurogenic locus notch homolog protein 3

Ligandability

Cysteine 1428 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

Cysteine 1433 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Neurogenic locus notch homolog protein 3 between cysteines 1401 and 1417.

Details

Redox score ?

PDB code

Structure name

crystal structure of notch3 nrr in complex with 20350 fab

Structure deposition date

2015-08-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

1401

Residue number B

1417

Peptide name

Neurogenic locus notch homolog protein 3

Ligandability

Cysteine 1401 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

Cysteine 1417 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Neurogenic locus notch homolog protein 3 between cysteines 1392 and 1410.

Details

Redox score ?

PDB code

Structure name

crystal structure of notch3 nrr in complex with 20358 fab

Structure deposition date

2015-08-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

1392

Residue number B

1410

Peptide name

Neurogenic locus notch homolog protein 3

Ligandability

Cysteine 1392 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

Cysteine 1410 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Neurogenic locus notch homolog protein 3 between cysteines 1467 and 1475.

Details

Redox score ?

PDB code

Structure name

crystal structure of notch3 nrr in complex with 20350 fab

Structure deposition date

2015-08-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

1467

Residue number B

1475

Peptide name

Neurogenic locus notch homolog protein 3

Ligandability

Cysteine 1467 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

Cysteine 1475 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Neurogenic locus notch homolog protein 3 between cysteines 1433 and 1451.

Details

Redox score ?

PDB code

Structure name

crystal structure of notch3 nrr in complex with 20358 fab

Structure deposition date

2015-08-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

1433

Residue number B

1451

Peptide name

Neurogenic locus notch homolog protein 3

Ligandability

Cysteine 1433 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

Cysteine 1451 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Neurogenic locus notch homolog protein 3 between cysteines 1428 and 1446.

Details

Redox score ?

PDB code

Structure name

crystal structure of notch3 nrr in complex with 20358 fab

Structure deposition date

2015-08-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

1428

Residue number B

1446

Peptide name

Neurogenic locus notch homolog protein 3

Ligandability

Cysteine 1428 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

Cysteine 1446 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Neurogenic locus notch homolog protein 3 between cysteines 1475 and 1493.

Details

Redox score ?

PDB code

Structure name

crystal structure of notch3 nrr in complex with 20350 fab

Structure deposition date

2015-08-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

1475

Residue number B

1493

Peptide name

Neurogenic locus notch homolog protein 3

Ligandability

Cysteine 1475 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

Cysteine 1493 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Neurogenic locus notch homolog protein 3 between cysteines 1387 and 1392.

Details

Redox score ?

PDB code

Structure name

crystal structure of notch3 nrr in complex with 20358 fab

Structure deposition date

2015-08-01

Thiol separation (Å)

Half-sphere exposure sum ?

nan

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

1387

Residue number B

1392

Peptide name

Neurogenic locus notch homolog protein 3

Ligandability

Cysteine 1387 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

Cysteine 1392 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Neurogenic locus notch homolog protein 3 between cysteines 1405 and 1410.

Details

Redox score ?

PDB code

Structure name

crystal structure of notch3 nrr in complex with 20358 fab

Structure deposition date

2015-08-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

1405

Residue number B

1410

Peptide name

Neurogenic locus notch homolog protein 3

Ligandability

Cysteine 1405 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

Cysteine 1410 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Neurogenic locus notch homolog protein 3 between cysteines 1446 and 1451.

Details

Redox score ?

PDB code

Structure name

crystal structure of notch3 nrr in complex with 20358 fab

Structure deposition date

2015-08-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

1446

Residue number B

1451

Peptide name

Neurogenic locus notch homolog protein 3

Ligandability

Cysteine 1446 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

Cysteine 1451 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Neurogenic locus notch homolog protein 3 between cysteines 1467 and 1488. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

crystal structure of notch3 nrr in complex with 20358 fab

Structure deposition date

2015-08-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

1467

Residue number B

1488

Peptide name

Neurogenic locus notch homolog protein 3

Ligandability

Cysteine 1467 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

Cysteine 1488 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Neurogenic locus notch homolog protein 3 between cysteines 1387 and 1405. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

crystal structure of notch3 nrr in complex with 20358 fab

Structure deposition date

2015-08-01

Thiol separation (Å)

Half-sphere exposure sum ?

nan

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

1387

Residue number B

1405

Peptide name

Neurogenic locus notch homolog protein 3

Ligandability

Cysteine 1387 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

Cysteine 1405 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Neurogenic locus notch homolog protein 3 between cysteines 1488 and 1493. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

crystal structure of notch3 nrr in complex with 20358 fab

Structure deposition date

2015-08-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

1488

Residue number B

1493

Peptide name

Neurogenic locus notch homolog protein 3

Ligandability

Cysteine 1488 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

Cysteine 1493 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Neurogenic locus notch homolog protein 3 between cysteines 1488 and 1500. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

crystal structure of notch3 nrr in complex with 20350 fab

Structure deposition date

2015-08-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

1488

Residue number B

1500

Peptide name

Neurogenic locus notch homolog protein 3

Ligandability

Cysteine 1488 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

Cysteine 1500 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Neurogenic locus notch homolog protein 3 between cysteines 1401 and 1405. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

crystal structure of notch3 nrr in complex with 20350 fab

Structure deposition date

2015-08-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

1401

Residue number B

1405

Peptide name

Neurogenic locus notch homolog protein 3

Ligandability

Cysteine 1401 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

Cysteine 1405 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Neurogenic locus notch homolog protein 3 between cysteines 1405 and 1417. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

crystal structure of notch3 nrr in complex with 20358 fab

Structure deposition date

2015-08-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

1405

Residue number B

1417

Peptide name

Neurogenic locus notch homolog protein 3

Ligandability

Cysteine 1405 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

Cysteine 1417 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Neurogenic locus notch homolog protein 3 between cysteines 1484 and 1488. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

crystal structure of notch3 nrr in complex with 20358 fab

Structure deposition date

2015-08-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

1484

Residue number B

1488

Peptide name

Neurogenic locus notch homolog protein 3

Ligandability

Cysteine 1484 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

Cysteine 1488 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Neurogenic locus notch homolog protein 3 between cysteines 1446 and 1458. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

crystal structure of notch3 nrr in complex with 20350 fab

Structure deposition date

2015-08-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

1446

Residue number B

1458

Peptide name

Neurogenic locus notch homolog protein 3

Ligandability

Cysteine 1446 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

Cysteine 1458 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Neurogenic locus notch homolog protein 3 between cysteines 1442 and 1446. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

crystal structure of notch3 nrr in complex with 20358 fab

Structure deposition date

2015-08-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

1442

Residue number B

1446

Peptide name

Neurogenic locus notch homolog protein 3

Ligandability

Cysteine 1442 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

Cysteine 1446 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Neurogenic locus notch homolog protein 3 between cysteines 1392 and 1417. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

crystal structure of notch3 nrr in complex with 20358 fab

Structure deposition date

2015-08-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

1392

Residue number B

1417

Peptide name

Neurogenic locus notch homolog protein 3

Ligandability

Cysteine 1392 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.

Cysteine 1417 of Neurogenic locus notch homolog protein 3

Not ligandable in the dataset of Vinogradova et al.