ALK tyrosine kinase receptor
Intermolecular
Cysteine 91 of Fibroblast growth factor receptor substrate 3 and cysteine 1579
Intramolecular
Cysteine 1008 and cysteine 1021
Cysteine 990 and cysteine 1006
Cysteine 987 and cysteine 995
Cysteine 783 and cysteine 794
Cysteine 688 and cysteine 701
Cysteine 906 and cysteine 928
Cysteine 990 and cysteine 995
Cysteine 987 and cysteine 990
Cysteine 995 and cysteine 1006
More...Cysteine 1006 and cysteine 1008
Cysteine 1006 and cysteine 1021
Cysteine 987 and cysteine 1006
Cysteine 990 and cysteine 1021
Cysteine 990 and cysteine 1008
Cysteine 995 and cysteine 1008
Cysteine 995 and cysteine 1021
Cysteine 987 and cysteine 1008
Cysteine 1237 and cysteine 1579
Cysteine 987 and cysteine 1021
Cysteine 1237 and cysteine 1255
Cysteine 1354 and cysteine 1386
Cysteine 1235 and cysteine 1237
Cysteine 1237 and cysteine 1365
Cysteine 61 and cysteine 928
2ys5 A 91 B 9
A redox-regulated disulphide may form between cysteine 91 of Fibroblast growth factor receptor substrate 3 and cysteine 1579 of ALK tyrosine kinase receptor (91 and 9 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
2ys5
Structure name
solution structure of the complex of the ptb domain of snt-2 and 19- residue peptide (aa 1571-1589) of halk
Structure deposition date
2007-04-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
56
Peptide A name
Fibroblast growth factor receptor substrate 3
Peptide B name
ALK tyrosine kinase receptor
Peptide A accession
O43559
Peptide B accession
Q9UM73
Peptide A residue number
91
Peptide B residue number
1579
Ligandability
Cysteine 91 of Fibroblast growth factor receptor substrate 3
Cysteine 1579 of ALK tyrosine kinase receptor
7nx4 A 1008 A 1021
A redox-regulated disulphide may form within ALK tyrosine kinase receptor between cysteines 1008 and 1021.
Details
Redox score ?
88
PDB code
7nx4
Structure name
crystal structure of the tg and egf-like domains of alk
Structure deposition date
2021-03-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UM73
Residue number A
1008
Residue number B
1021
Peptide name
ALK tyrosine kinase receptor
Ligandability
Cysteine 1008 of ALK tyrosine kinase receptor
Cysteine 1021 of ALK tyrosine kinase receptor
7nx4 A 990 A 1006
A redox-regulated disulphide may form within ALK tyrosine kinase receptor between cysteines 990 and 1006.
Details
Redox score ?
88
PDB code
7nx4
Structure name
crystal structure of the tg and egf-like domains of alk
Structure deposition date
2021-03-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UM73
Residue number A
990
Residue number B
1006
Peptide name
ALK tyrosine kinase receptor
Ligandability
Cysteine 990 of ALK tyrosine kinase receptor
Cysteine 1006 of ALK tyrosine kinase receptor
7nx4 A 987 A 995
A redox-regulated disulphide may form within ALK tyrosine kinase receptor between cysteines 987 and 995.
Details
Redox score ?
87
PDB code
7nx4
Structure name
crystal structure of the tg and egf-like domains of alk
Structure deposition date
2021-03-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UM73
Residue number A
987
Residue number B
995
Peptide name
ALK tyrosine kinase receptor
Ligandability
Cysteine 987 of ALK tyrosine kinase receptor
Cysteine 995 of ALK tyrosine kinase receptor
7nwz A 783 A 794
A redox-regulated disulphide may form within ALK tyrosine kinase receptor between cysteines 783 and 794.
Details
Redox score ?
81
PDB code
7nwz
Structure name
alk:alkal2 complex
Structure deposition date
2021-03-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UM73
Residue number A
783
Residue number B
794
Peptide name
ALK tyrosine kinase receptor
Ligandability
Cysteine 783 of ALK tyrosine kinase receptor
Cysteine 794 of ALK tyrosine kinase receptor
7nwz A 688 A 701
A redox-regulated disulphide may form within ALK tyrosine kinase receptor between cysteines 688 and 701.
Details
Redox score ?
80
PDB code
7nwz
Structure name
alk:alkal2 complex
Structure deposition date
2021-03-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UM73
Residue number A
688
Residue number B
701
Peptide name
ALK tyrosine kinase receptor
Ligandability
Cysteine 688 of ALK tyrosine kinase receptor
Cysteine 701 of ALK tyrosine kinase receptor
7nwz F 906 F 928
A redox-regulated disulphide may form within ALK tyrosine kinase receptor between cysteines 906 and 928.
Details
Redox score ?
75
PDB code
7nwz
Structure name
alk:alkal2 complex
Structure deposition date
2021-03-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
110
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UM73
Residue number A
906
Residue number B
928
Peptide name
ALK tyrosine kinase receptor
Ligandability
Cysteine 906 of ALK tyrosine kinase receptor
Cysteine 928 of ALK tyrosine kinase receptor
7nx4 A 990 A 995
A redox-regulated disulphide may form within ALK tyrosine kinase receptor between cysteines 990 and 995.
Details
Redox score ?
73
PDB code
7nx4
Structure name
crystal structure of the tg and egf-like domains of alk
Structure deposition date
2021-03-17
Thiol separation (Å)
5
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UM73
Residue number A
990
Residue number B
995
Peptide name
ALK tyrosine kinase receptor
Ligandability
Cysteine 990 of ALK tyrosine kinase receptor
Cysteine 995 of ALK tyrosine kinase receptor
7nx4 A 987 A 990
A redox-regulated disulphide may form within ALK tyrosine kinase receptor between cysteines 987 and 990.
Details
Redox score ?
71
PDB code
7nx4
Structure name
crystal structure of the tg and egf-like domains of alk
Structure deposition date
2021-03-17
Thiol separation (Å)
5
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UM73
Residue number A
987
Residue number B
990
Peptide name
ALK tyrosine kinase receptor
Ligandability
Cysteine 987 of ALK tyrosine kinase receptor
Cysteine 990 of ALK tyrosine kinase receptor
7nx4 A 995 A 1006
A redox-regulated disulphide may form within ALK tyrosine kinase receptor between cysteines 995 and 1006.
Details
Redox score ?
62
PDB code
7nx4
Structure name
crystal structure of the tg and egf-like domains of alk
Structure deposition date
2021-03-17
Thiol separation (Å)
6
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UM73
Residue number A
995
Residue number B
1006
Peptide name
ALK tyrosine kinase receptor
Ligandability
Cysteine 995 of ALK tyrosine kinase receptor
Cysteine 1006 of ALK tyrosine kinase receptor
7nx4 A 1006 A 1008
A redox-regulated disulphide may form within ALK tyrosine kinase receptor between cysteines 1006 and 1008.
Details
Redox score ?
60
PDB code
7nx4
Structure name
crystal structure of the tg and egf-like domains of alk
Structure deposition date
2021-03-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UM73
Residue number A
1006
Residue number B
1008
Peptide name
ALK tyrosine kinase receptor
Ligandability
Cysteine 1006 of ALK tyrosine kinase receptor
Cysteine 1008 of ALK tyrosine kinase receptor
7nx4 A 1006 A 1021
A redox-regulated disulphide may form within ALK tyrosine kinase receptor between cysteines 1006 and 1021. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
7nx4
Structure name
crystal structure of the tg and egf-like domains of alk
Structure deposition date
2021-03-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UM73
Residue number A
1006
Residue number B
1021
Peptide name
ALK tyrosine kinase receptor
Ligandability
Cysteine 1006 of ALK tyrosine kinase receptor
Cysteine 1021 of ALK tyrosine kinase receptor
7nx4 A 987 A 1006
A redox-regulated disulphide may form within ALK tyrosine kinase receptor between cysteines 987 and 1006. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
7nx4
Structure name
crystal structure of the tg and egf-like domains of alk
Structure deposition date
2021-03-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UM73
Residue number A
987
Residue number B
1006
Peptide name
ALK tyrosine kinase receptor
Ligandability
Cysteine 987 of ALK tyrosine kinase receptor
Cysteine 1006 of ALK tyrosine kinase receptor
7nx4 A 990 A 1021
A redox-regulated disulphide may form within ALK tyrosine kinase receptor between cysteines 990 and 1021. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
7nx4
Structure name
crystal structure of the tg and egf-like domains of alk
Structure deposition date
2021-03-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UM73
Residue number A
990
Residue number B
1021
Peptide name
ALK tyrosine kinase receptor
Ligandability
Cysteine 990 of ALK tyrosine kinase receptor
Cysteine 1021 of ALK tyrosine kinase receptor
7nx4 A 990 A 1008
A redox-regulated disulphide may form within ALK tyrosine kinase receptor between cysteines 990 and 1008. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
7nx4
Structure name
crystal structure of the tg and egf-like domains of alk
Structure deposition date
2021-03-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UM73
Residue number A
990
Residue number B
1008
Peptide name
ALK tyrosine kinase receptor
Ligandability
Cysteine 990 of ALK tyrosine kinase receptor
Cysteine 1008 of ALK tyrosine kinase receptor
7mzw A 995 A 1008
A redox-regulated disulphide may form within ALK tyrosine kinase receptor between cysteines 995 and 1008. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
7mzw
Structure name
anaplastic lymphoma kinase (alk) extracellular ligand binding region 673-1025
Structure deposition date
2021-05-24
Thiol separation (Å)
7
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UM73
Residue number A
995
Residue number B
1008
Peptide name
ALK tyrosine kinase receptor
Ligandability
Cysteine 995 of ALK tyrosine kinase receptor
Cysteine 1008 of ALK tyrosine kinase receptor
7mzw A 995 A 1021
A redox-regulated disulphide may form within ALK tyrosine kinase receptor between cysteines 995 and 1021. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
7mzw
Structure name
anaplastic lymphoma kinase (alk) extracellular ligand binding region 673-1025
Structure deposition date
2021-05-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UM73
Residue number A
995
Residue number B
1021
Peptide name
ALK tyrosine kinase receptor
Ligandability
Cysteine 995 of ALK tyrosine kinase receptor
Cysteine 1021 of ALK tyrosine kinase receptor
7mzw A 987 A 1008
A redox-regulated disulphide may form within ALK tyrosine kinase receptor between cysteines 987 and 1008. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
7mzw
Structure name
anaplastic lymphoma kinase (alk) extracellular ligand binding region 673-1025
Structure deposition date
2021-05-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UM73
Residue number A
987
Residue number B
1008
Peptide name
ALK tyrosine kinase receptor
Ligandability
Cysteine 987 of ALK tyrosine kinase receptor
Cysteine 1008 of ALK tyrosine kinase receptor
2kuq A 91 A 143
A redox-regulated disulphide may form within ALK tyrosine kinase receptor between cysteines 1237 and 1579 (91 and 143 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
2kuq
Structure name
solution structure of the chimera of the ptb domain of snt-2 and 19- residue peptide (aa 1571-1589) of halk
Structure deposition date
2010-02-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
57
Minimum pKa ?
11
% buried
60
Peptide accession
Q9UM73
Residue number A
1237
Residue number B
1579
Peptide name
ALK tyrosine kinase receptor
Ligandability
Cysteine 1237 of ALK tyrosine kinase receptor
Cysteine 1579 of ALK tyrosine kinase receptor
7mzw A 987 A 1021
A redox-regulated disulphide may form within ALK tyrosine kinase receptor between cysteines 987 and 1021. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7mzw
Structure name
anaplastic lymphoma kinase (alk) extracellular ligand binding region 673-1025
Structure deposition date
2021-05-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UM73
Residue number A
987
Residue number B
1021
Peptide name
ALK tyrosine kinase receptor
Ligandability
Cysteine 987 of ALK tyrosine kinase receptor
Cysteine 1021 of ALK tyrosine kinase receptor
7jyr A 1237 A 1255
A redox-regulated disulphide may form within ALK tyrosine kinase receptor between cysteines 1237 and 1255. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
7jyr
Structure name
halk in complex with 1-[(1r,2r)-1-(2,4-difluorophenyl)-2-[2-(5-methyl- 1h-pyrazol-3-yl)-4-(trifluoromethyl)phenoxy]cyclopropyl]methanamine
Structure deposition date
2020-08-31
Thiol separation (Å)
7
Half-sphere exposure sum ?
86
Minimum pKa ?
13
% buried
100
Peptide accession
Q9UM73
Residue number A
1237
Residue number B
1255
Peptide name
ALK tyrosine kinase receptor
Ligandability
Cysteine 1237 of ALK tyrosine kinase receptor
Cysteine 1255 of ALK tyrosine kinase receptor
4cnh A 1354 A 1386
A redox-regulated disulphide may form within ALK tyrosine kinase receptor between cysteines 1354 and 1386. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
4cnh
Structure name
structure of the human anaplastic lymphoma kinase in complex with the inhibitor 3-((1r)-1-(5-fluoro-2-methoxyphenyl)ethoxy)-5-(1-methyl-1h- 1,2,3-triazol-5-yl)pyridin-2-amine
Structure deposition date
2014-01-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
12
% buried
89
Peptide accession
Q9UM73
Residue number A
1354
Residue number B
1386
Peptide name
ALK tyrosine kinase receptor
Ligandability
Cysteine 1354 of ALK tyrosine kinase receptor
Cysteine 1386 of ALK tyrosine kinase receptor
5imx A 1235 A 1237
A redox-regulated disulphide may form within ALK tyrosine kinase receptor between cysteines 1235 and 1237. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
31
PDB code
5imx
Structure name
anaplastic lymphoma kinase (alk) catalytic domain complexed with novel inhibitor 3-sulfonylpyrazol-4-amino pyrimidine
Structure deposition date
2016-03-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
80
Minimum pKa ?
10
% buried
68
Peptide accession
Q9UM73
Residue number A
1235
Residue number B
1237
Peptide name
ALK tyrosine kinase receptor
Ligandability
Cysteine 1235 of ALK tyrosine kinase receptor
Cysteine 1237 of ALK tyrosine kinase receptor
4joa A 1237 A 1365
A redox-regulated disulphide may form within ALK tyrosine kinase receptor between cysteines 1237 and 1365. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
26
PDB code
4joa
Structure name
crystal structure of human anaplastic lymphoma kinase in complex with 7-azaindole based inhibitor
Structure deposition date
2013-03-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
86
Minimum pKa ?
12
% buried
100
Peptide accession
Q9UM73
Residue number A
1237
Residue number B
1365
Peptide name
ALK tyrosine kinase receptor
Ligandability
Cysteine 1237 of ALK tyrosine kinase receptor
Cysteine 1365 of ALK tyrosine kinase receptor
2kuq A 61 A 80
A redox-regulated disulphide may form within ALK tyrosine kinase receptor between cysteines 61 and 928 (61 and 80 respectively in this structure).
Details
Redox score ?
nan
PDB code
2kuq
Structure name
solution structure of the chimera of the ptb domain of snt-2 and 19- residue peptide (aa 1571-1589) of halk
Structure deposition date
2010-02-24
Thiol separation (Å)
7
Half-sphere exposure sum ?
49
Minimum pKa ?
8
% buried
22
Peptide accession
Q9UM73
Residue number A
61
Residue number B
928
Peptide name
ALK tyrosine kinase receptor
Ligandability
Cysteine 61 of ALK tyrosine kinase receptor
Cysteine 928 of ALK tyrosine kinase receptor
Cysteine 61 in protein A could not be asigned to a Uniprot residue.
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