ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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ATP-dependent RNA helicase DDX19B

Intramolecular
Cysteine 165 and cysteine 268
Cysteine 165 and cysteine 167
A redox-regulated disulphide may form within ATP-dependent RNA helicase DDX19B between cysteines 165 and 268. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
3fmo
Structure name
crystal structure of the nucleoporin nup214 in complex with the dead- box helicase ddx19
Structure deposition date
2008-12-22
Thiol separation (Å)
8
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
92
Peptide accession
Q9UMR2
Residue number A
165
Residue number B
268
Peptide name
ATP-dependent RNA helicase DDX19B

Ligandability

Cysteine 165 of ATP-dependent RNA helicase DDX19B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 268 of ATP-dependent RNA helicase DDX19B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ATP-dependent RNA helicase DDX19B between cysteines 165 and 167. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
21
PDB code
3ews
Structure name
human dead-box rna-helicase ddx19 in complex with adp
Structure deposition date
2008-10-16
Thiol separation (Å)
10
Half-sphere exposure sum ?
98
Minimum pKa ?
12
% buried
100
Peptide accession
Q9UMR2
Residue number A
165
Residue number B
167
Peptide name
ATP-dependent RNA helicase DDX19B

Ligandability

Cysteine 165 of ATP-dependent RNA helicase DDX19B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 167 of ATP-dependent RNA helicase DDX19B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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