ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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C-type lectin domain family 4 member A

Intermolecular
Cysteine 222 and cysteine 222
Cysteine 222 and cysteine 203
Intramolecular
Cysteine 106 and cysteine 117
Cysteine 134 and cysteine 230
A redox-regulated disulphide may form between two units of C-type lectin domain family 4 member A at cysteines 222 and 222. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
5b1w
Structure name
crystal structure of human dendritic cell inhibitory receptor (dcir) c-type lectin domain in ligand-free form
Structure deposition date
2015-12-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
98
Minimum pKa ?
nan
% buried
nan
Peptide A name
C-type lectin domain family 4 member A
Peptide B name
C-type lectin domain family 4 member A
Peptide A accession
Q9UMR7
Peptide B accession
Q9UMR7
Peptide A residue number
222
Peptide B residue number
222

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of C-type lectin domain family 4 member A at cysteines 222 and 203. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
5b1w
Structure name
crystal structure of human dendritic cell inhibitory receptor (dcir) c-type lectin domain in ligand-free form
Structure deposition date
2015-12-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
100
Minimum pKa ?
nan
% buried
nan
Peptide A name
C-type lectin domain family 4 member A
Peptide B name
C-type lectin domain family 4 member A
Peptide A accession
Q9UMR7
Peptide B accession
Q9UMR7
Peptide A residue number
222
Peptide B residue number
203

Ligandability

Cysteine 222 of C-type lectin domain family 4 member A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 203 of C-type lectin domain family 4 member A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within C-type lectin domain family 4 member A between cysteines 106 and 117.

Details

Redox score ?
87
PDB code
5b1x
Structure name
crystal structure of human dendritic cell inhibitory receptor (dcir) c-type lectin domain in complex with biantennary glycan
Structure deposition date
2015-12-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UMR7
Residue number A
106
Residue number B
117
Peptide name
C-type lectin domain family 4 member A

Ligandability

Cysteine 106 of C-type lectin domain family 4 member A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 117 of C-type lectin domain family 4 member A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within C-type lectin domain family 4 member A between cysteines 134 and 230.

Details

Redox score ?
82
PDB code
5b1w
Structure name
crystal structure of human dendritic cell inhibitory receptor (dcir) c-type lectin domain in ligand-free form
Structure deposition date
2015-12-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UMR7
Residue number A
134
Residue number B
230
Peptide name
C-type lectin domain family 4 member A

Ligandability

Cysteine 134 of C-type lectin domain family 4 member A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 230 of C-type lectin domain family 4 member A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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