ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Ubl carboxyl-terminal hydrolase 18

Intermolecular
Cysteine 336 and cysteine 336
Cysteine 345 and cysteine 345
Intramolecular
Cysteine 175 and cysteine 226
Cysteine 226 and cysteine 229
Cysteine 178 and cysteine 226
Cysteine 175 and cysteine 229
Cysteine 175 and cysteine 178
Cysteine 178 and cysteine 229
Cysteine 316 and cysteine 329
Cysteine 225 and cysteine 226
More...
Cysteine 175 and cysteine 225
Cysteine 225 and cysteine 229
Cysteine 329 and cysteine 336
Cysteine 61 and cysteine 62
Cysteine 316 and cysteine 336
Cysteine 61 and cysteine 316
A redox-regulated disulphide may form between two units of Ubl carboxyl-terminal hydrolase 18 at cysteines 336 and 336. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
5cht
Structure name
crystal structure of usp18
Structure deposition date
2015-07-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
15
% buried
nan
Peptide A name
Ubl carboxyl-terminal hydrolase 18
Peptide B name
Ubl carboxyl-terminal hydrolase 18
Peptide A accession
Q9WTV6
Peptide B accession
Q9WTV6
Peptide A residue number
336
Peptide B residue number
336

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Ubl carboxyl-terminal hydrolase 18 at cysteines 345 and 345. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
5chv
Structure name
crystal structure of usp18-isg15 complex
Structure deposition date
2015-07-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
55
Minimum pKa ?
10
% buried
60
Peptide A name
Ubl carboxyl-terminal hydrolase 18
Peptide B name
Ubl carboxyl-terminal hydrolase 18
Peptide A accession
Q9WTV6
Peptide B accession
Q9WTV6
Peptide A residue number
345
Peptide B residue number
345

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ubl carboxyl-terminal hydrolase 18 between cysteines 175 and 226.

Details

Redox score ?
89
PDB code
5cht
Structure name
crystal structure of usp18
Structure deposition date
2015-07-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
5
% buried
0
Peptide accession
Q9WTV6
Residue number A
175
Residue number B
226
Peptide name
Ubl carboxyl-terminal hydrolase 18

Ligandability

Cysteine 175 of Ubl carboxyl-terminal hydrolase 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 226 of Ubl carboxyl-terminal hydrolase 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ubl carboxyl-terminal hydrolase 18 between cysteines 226 and 229.

Details

Redox score ?
89
PDB code
5chv
Structure name
crystal structure of usp18-isg15 complex
Structure deposition date
2015-07-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
41
Minimum pKa ?
7
% buried
0
Peptide accession
Q9WTV6
Residue number A
226
Residue number B
229
Peptide name
Ubl carboxyl-terminal hydrolase 18

Ligandability

Cysteine 226 of Ubl carboxyl-terminal hydrolase 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 229 of Ubl carboxyl-terminal hydrolase 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ubl carboxyl-terminal hydrolase 18 between cysteines 178 and 226.

Details

Redox score ?
87
PDB code
5cht
Structure name
crystal structure of usp18
Structure deposition date
2015-07-10
Thiol separation (Å)
3
Half-sphere exposure sum ?
44
Minimum pKa ?
7
% buried
0
Peptide accession
Q9WTV6
Residue number A
178
Residue number B
226
Peptide name
Ubl carboxyl-terminal hydrolase 18

Ligandability

Cysteine 178 of Ubl carboxyl-terminal hydrolase 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 226 of Ubl carboxyl-terminal hydrolase 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ubl carboxyl-terminal hydrolase 18 between cysteines 175 and 229.

Details

Redox score ?
87
PDB code
5cht
Structure name
crystal structure of usp18
Structure deposition date
2015-07-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
5
% buried
0
Peptide accession
Q9WTV6
Residue number A
175
Residue number B
229
Peptide name
Ubl carboxyl-terminal hydrolase 18

Ligandability

Cysteine 175 of Ubl carboxyl-terminal hydrolase 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 229 of Ubl carboxyl-terminal hydrolase 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ubl carboxyl-terminal hydrolase 18 between cysteines 175 and 178.

Details

Redox score ?
86
PDB code
5chv
Structure name
crystal structure of usp18-isg15 complex
Structure deposition date
2015-07-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
6
% buried
0
Peptide accession
Q9WTV6
Residue number A
175
Residue number B
178
Peptide name
Ubl carboxyl-terminal hydrolase 18

Ligandability

Cysteine 175 of Ubl carboxyl-terminal hydrolase 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 178 of Ubl carboxyl-terminal hydrolase 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ubl carboxyl-terminal hydrolase 18 between cysteines 178 and 229.

Details

Redox score ?
80
PDB code
5cht
Structure name
crystal structure of usp18
Structure deposition date
2015-07-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
34
Minimum pKa ?
10
% buried
0
Peptide accession
Q9WTV6
Residue number A
178
Residue number B
229
Peptide name
Ubl carboxyl-terminal hydrolase 18

Ligandability

Cysteine 178 of Ubl carboxyl-terminal hydrolase 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 229 of Ubl carboxyl-terminal hydrolase 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ubl carboxyl-terminal hydrolase 18 between cysteines 316 and 329.

Details

Redox score ?
63
PDB code
5chv
Structure name
crystal structure of usp18-isg15 complex
Structure deposition date
2015-07-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
85
Minimum pKa ?
8
% buried
100
Peptide accession
Q9WTV6
Residue number A
316
Residue number B
329
Peptide name
Ubl carboxyl-terminal hydrolase 18

Ligandability

Cysteine 316 of Ubl carboxyl-terminal hydrolase 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 329 of Ubl carboxyl-terminal hydrolase 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ubl carboxyl-terminal hydrolase 18 between cysteines 225 and 226. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
5chv
Structure name
crystal structure of usp18-isg15 complex
Structure deposition date
2015-07-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
48
Minimum pKa ?
7
% buried
0
Peptide accession
Q9WTV6
Residue number A
225
Residue number B
226
Peptide name
Ubl carboxyl-terminal hydrolase 18

Ligandability

Cysteine 225 of Ubl carboxyl-terminal hydrolase 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 226 of Ubl carboxyl-terminal hydrolase 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ubl carboxyl-terminal hydrolase 18 between cysteines 175 and 225. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
5cht
Structure name
crystal structure of usp18
Structure deposition date
2015-07-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
51
Minimum pKa ?
5
% buried
0
Peptide accession
Q9WTV6
Residue number A
175
Residue number B
225
Peptide name
Ubl carboxyl-terminal hydrolase 18

Ligandability

Cysteine 175 of Ubl carboxyl-terminal hydrolase 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 225 of Ubl carboxyl-terminal hydrolase 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ubl carboxyl-terminal hydrolase 18 between cysteines 225 and 229. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
5chv
Structure name
crystal structure of usp18-isg15 complex
Structure deposition date
2015-07-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
39
Minimum pKa ?
9
% buried
0
Peptide accession
Q9WTV6
Residue number A
225
Residue number B
229
Peptide name
Ubl carboxyl-terminal hydrolase 18

Ligandability

Cysteine 225 of Ubl carboxyl-terminal hydrolase 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 229 of Ubl carboxyl-terminal hydrolase 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ubl carboxyl-terminal hydrolase 18 between cysteines 329 and 336. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
5cht
Structure name
crystal structure of usp18
Structure deposition date
2015-07-10
Thiol separation (Å)
5
Half-sphere exposure sum ?
73
Minimum pKa ?
21
% buried
nan
Peptide accession
Q9WTV6
Residue number A
329
Residue number B
336
Peptide name
Ubl carboxyl-terminal hydrolase 18

Ligandability

Cysteine 329 of Ubl carboxyl-terminal hydrolase 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 336 of Ubl carboxyl-terminal hydrolase 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ubl carboxyl-terminal hydrolase 18 between cysteines 61 and 62. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
5cht
Structure name
crystal structure of usp18
Structure deposition date
2015-07-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
80
Minimum pKa ?
13
% buried
100
Peptide accession
Q9WTV6
Residue number A
61
Residue number B
62
Peptide name
Ubl carboxyl-terminal hydrolase 18

Ligandability

Cysteine 61 of Ubl carboxyl-terminal hydrolase 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 62 of Ubl carboxyl-terminal hydrolase 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ubl carboxyl-terminal hydrolase 18 between cysteines 316 and 336. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
5cht
Structure name
crystal structure of usp18
Structure deposition date
2015-07-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
80
Minimum pKa ?
10
% buried
nan
Peptide accession
Q9WTV6
Residue number A
316
Residue number B
336
Peptide name
Ubl carboxyl-terminal hydrolase 18

Ligandability

Cysteine 316 of Ubl carboxyl-terminal hydrolase 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 336 of Ubl carboxyl-terminal hydrolase 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ubl carboxyl-terminal hydrolase 18 between cysteines 61 and 316. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
23
PDB code
5chv
Structure name
crystal structure of usp18-isg15 complex
Structure deposition date
2015-07-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
90
Minimum pKa ?
16
% buried
100
Peptide accession
Q9WTV6
Residue number A
61
Residue number B
316
Peptide name
Ubl carboxyl-terminal hydrolase 18

Ligandability

Cysteine 61 of Ubl carboxyl-terminal hydrolase 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 316 of Ubl carboxyl-terminal hydrolase 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: