ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

Intramolecular
Cysteine 227 and cysteine 240
Cysteine 213 and cysteine 229
Cysteine 227 and cysteine 229
Cysteine 229 and cysteine 240
A redox-regulated disulphide may form within Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide between cysteines 227 and 240.

Details

Redox score ?
78
PDB code
1fao
Structure name
structure of the pleckstrin homology domain from dapp1/phish in complex with inositol 1,3,4,5- tetrakisphosphate
Structure deposition date
2000-07-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UN19
Residue number A
227
Residue number B
240
Peptide name
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

Ligandability

Cysteine 227 of Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 240 of Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide between cysteines 213 and 229. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
1fao
Structure name
structure of the pleckstrin homology domain from dapp1/phish in complex with inositol 1,3,4,5- tetrakisphosphate
Structure deposition date
2000-07-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
45
Peptide accession
Q9UN19
Residue number A
213
Residue number B
229
Peptide name
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

Ligandability

Cysteine 213 of Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 229 of Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide between cysteines 227 and 229. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
1fao
Structure name
structure of the pleckstrin homology domain from dapp1/phish in complex with inositol 1,3,4,5- tetrakisphosphate
Structure deposition date
2000-07-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
nan
Peptide accession
Q9UN19
Residue number A
227
Residue number B
229
Peptide name
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

Ligandability

Cysteine 227 of Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 229 of Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide between cysteines 229 and 240. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
1fao
Structure name
structure of the pleckstrin homology domain from dapp1/phish in complex with inositol 1,3,4,5- tetrakisphosphate
Structure deposition date
2000-07-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
nan
Peptide accession
Q9UN19
Residue number A
229
Residue number B
240
Peptide name
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

Ligandability

Cysteine 229 of Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 240 of Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: