DNA polymerase iota
Intramolecular
Cysteine 434 and cysteine 436
Cysteine 62 and cysteine 91
Cysteine 91 and cysteine 113
Cysteine 387 and cysteine 436
Cysteine 62 and cysteine 221
4eyh B 409 B 411
A redox-regulated disulphide may form within DNA polymerase iota between cysteines 434 and 436 (409 and 411 respectively in this structure).
Details
Redox score ?
68
PDB code
4eyh
Structure name
human dna polymerase iota incorporating dctp opposite n- (deoxyguanosin-8-yl)-1-aminopyrene lesion
Structure deposition date
2012-05-01
Thiol separation (Å)
5
Half-sphere exposure sum ?
62
Minimum pKa ?
7
% buried
82
Peptide accession
Q9UNA4
Residue number A
434
Residue number B
436
Peptide name
DNA polymerase iota
Ligandability
Cysteine 434 of DNA polymerase iota
Cysteine 436 of DNA polymerase iota
5kt5 A 62 A 91
A redox-regulated disulphide may form within DNA polymerase iota between cysteines 62 and 91. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
5kt5
Structure name
teranry complex of human dna polymerase iota r96g inserting dcmpnpp opposite template g in the presence of mn2+
Structure deposition date
2016-07-11
Thiol separation (Å)
7
Half-sphere exposure sum ?
79
Minimum pKa ?
11
% buried
76
Peptide accession
Q9UNA4
Residue number A
62
Residue number B
91
Peptide name
DNA polymerase iota
Ligandability
Cysteine 62 of DNA polymerase iota
Cysteine 91 of DNA polymerase iota
5kt7 A 66 A 88
A redox-regulated disulphide may form within DNA polymerase iota between cysteines 91 and 113 (66 and 88 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
5kt7
Structure name
teranry complex of human dna polymerase iota(1-445) inserting dcmpnpp opposite template g in the presence of mn2+
Structure deposition date
2016-07-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
10
% buried
42
Peptide accession
Q9UNA4
Residue number A
91
Residue number B
113
Peptide name
DNA polymerase iota
Ligandability
Cysteine 91 of DNA polymerase iota
Cysteine 113 of DNA polymerase iota
4ebd A 362 A 411
A redox-regulated disulphide may form within DNA polymerase iota between cysteines 387 and 436 (362 and 411 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
4ebd
Structure name
conformationally restrained north-methanocarba-2'-deoxyadenosine corrects the error-prone nature of human dna polymerase iota
Structure deposition date
2012-03-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
47
Minimum pKa ?
7
% buried
52
Peptide accession
Q9UNA4
Residue number A
387
Residue number B
436
Peptide name
DNA polymerase iota
Ligandability
Cysteine 387 of DNA polymerase iota
Cysteine 436 of DNA polymerase iota
4eyi B 37 B 196
A redox-regulated disulphide may form within DNA polymerase iota between cysteines 62 and 221 (37 and 196 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
29
PDB code
4eyi
Structure name
human dna polymerase iota incorporating datp opposite n- (deoxyguanosin-8-yl)-1-aminopyrene lesion
Structure deposition date
2012-05-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
76
Minimum pKa ?
11
% buried
81
Peptide accession
Q9UNA4
Residue number A
62
Residue number B
221
Peptide name
DNA polymerase iota
Ligandability
Cysteine 62 of DNA polymerase iota
Cysteine 221 of DNA polymerase iota
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