a tool for identifying drug-targetable redox-active disulphides

Protein kinase C and casein kinase substrate in neurons protein 2

Intramolecular

Cysteine 163 and cysteine 197 L

A redox-regulated disulphide may form within Protein kinase C and casein kinase substrate in neurons protein 2 between cysteines 163 and 197 (164 and 198 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

44

PDB code

Structure name

crystal structure of human pacsin2 f-bar domain (p212121 lattice)

Structure deposition date

2009-05-01

Thiol separation (Å)

10

Half-sphere exposure sum ?

54

Minimum pK_a ?

10

% buried

1

Peptide accession

Residue number A

163

Residue number B

197

Peptide name

Protein kinase C and casein kinase substrate in neurons protein 2

Ligandability

Cysteine 163 of Protein kinase C and casein kinase substrate in neurons protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 197 of Protein kinase C and casein kinase substrate in neurons protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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