ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Tumor necrosis factor ligand superfamily member 18

Intramolecular
Cysteine 52 and cysteine 72
Cysteine 58 and cysteine 78
A redox-regulated disulphide may form within Tumor necrosis factor ligand superfamily member 18 between cysteines 52 and 72.

Details

Redox score ?
82
PDB code
2q8o
Structure name
crystal structure of mouse gitr ligand dimer
Structure deposition date
2007-06-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80YG2
Residue number A
52
Residue number B
72
Peptide name
Tumor necrosis factor ligand superfamily member 18

Ligandability

Cysteine 52 of Tumor necrosis factor ligand superfamily member 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 72 of Tumor necrosis factor ligand superfamily member 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor ligand superfamily member 18 between cysteines 58 and 78.

Details

Redox score ?
81
PDB code
7law
Structure name
crystal structure of gitr complex with gitr-l
Structure deposition date
2021-01-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UNG2
Residue number A
58
Residue number B
78
Peptide name
Tumor necrosis factor ligand superfamily member 18

Ligandability

Cysteine 58 of Tumor necrosis factor ligand superfamily member 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 78 of Tumor necrosis factor ligand superfamily member 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: