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a tool for identifying drug-targetable redox-active disulphides

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Inhibitor of growth protein 4

Intramolecular
Cysteine 239 and cysteine 242
Cysteine 217 and cysteine 239
Cysteine 217 and cysteine 242
Cysteine 199 and cysteine 201
Cysteine 212 and cysteine 242
Cysteine 199 and cysteine 226
Cysteine 212 and cysteine 239
Cysteine 212 and cysteine 217
Cysteine 201 and cysteine 226
Cysteine 199 and cysteine 212
More...
Cysteine 199 and cysteine 217
Cysteine 199 and cysteine 239
Cysteine 226 and cysteine 239
Cysteine 212 and cysteine 226
A redox-regulated disulphide may form within Inhibitor of growth protein 4 between cysteines 239 and 242 (79 and 82 respectively in this structure).

Details

Redox score ?
89
PDB code
1weu
Structure name
solution structure of phd domain in ing1-like protein bac25009
Structure deposition date
2004-05-25
Thiol separation (Å)
3
Half-sphere exposure sum ?
49
Minimum pKa ?
7
% buried
5
Peptide accession
Q8C0D7
Residue number A
239
Residue number B
242
Peptide name
Inhibitor of growth protein 4

Ligandability

Cysteine 239 of Inhibitor of growth protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 242 of Inhibitor of growth protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inhibitor of growth protein 4 between cysteines 217 and 239.

Details

Redox score ?
89
PDB code
2vnf
Structure name
molecular basis of histone h3k4me3 recognition by ing4
Structure deposition date
2008-02-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
6
% buried
12
Peptide accession
Q9UNL4
Residue number A
217
Residue number B
239
Peptide name
Inhibitor of growth protein 4

Ligandability

Cysteine 217 of Inhibitor of growth protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 239 of Inhibitor of growth protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inhibitor of growth protein 4 between cysteines 217 and 242 (37 and 62 respectively in this structure).

Details

Redox score ?
87
PDB code
1wen
Structure name
solution structure of phd domain in ing1-like protein bac25079
Structure deposition date
2004-05-25
Thiol separation (Å)
3
Half-sphere exposure sum ?
41
Minimum pKa ?
8
% buried
2
Peptide accession
Q8C0D7
Residue number A
217
Residue number B
242
Peptide name
Inhibitor of growth protein 4

Ligandability

Cysteine 217 of Inhibitor of growth protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 242 of Inhibitor of growth protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inhibitor of growth protein 4 between cysteines 199 and 201 (39 and 41 respectively in this structure).

Details

Redox score ?
85
PDB code
1weu
Structure name
solution structure of phd domain in ing1-like protein bac25009
Structure deposition date
2004-05-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
7
% buried
6
Peptide accession
Q8C0D7
Residue number A
199
Residue number B
201
Peptide name
Inhibitor of growth protein 4

Ligandability

Cysteine 199 of Inhibitor of growth protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 201 of Inhibitor of growth protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inhibitor of growth protein 4 between cysteines 212 and 242.

Details

Redox score ?
84
PDB code
2pnx
Structure name
the phd finger of ing4 in complex with an h3k4me3 histone peptide
Structure deposition date
2007-04-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
6
% buried
16
Peptide accession
Q9UNL4
Residue number A
212
Residue number B
242
Peptide name
Inhibitor of growth protein 4

Ligandability

Cysteine 212 of Inhibitor of growth protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 242 of Inhibitor of growth protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inhibitor of growth protein 4 between cysteines 199 and 226 (39 and 66 respectively in this structure).

Details

Redox score ?
83
PDB code
1weu
Structure name
solution structure of phd domain in ing1-like protein bac25009
Structure deposition date
2004-05-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
7
% buried
6
Peptide accession
Q8C0D7
Residue number A
199
Residue number B
226
Peptide name
Inhibitor of growth protein 4

Ligandability

Cysteine 199 of Inhibitor of growth protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 226 of Inhibitor of growth protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inhibitor of growth protein 4 between cysteines 212 and 239.

Details

Redox score ?
82
PDB code
2pnx
Structure name
the phd finger of ing4 in complex with an h3k4me3 histone peptide
Structure deposition date
2007-04-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
8
% buried
12
Peptide accession
Q9UNL4
Residue number A
212
Residue number B
239
Peptide name
Inhibitor of growth protein 4

Ligandability

Cysteine 212 of Inhibitor of growth protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 239 of Inhibitor of growth protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inhibitor of growth protein 4 between cysteines 212 and 217.

Details

Redox score ?
82
PDB code
2pnx
Structure name
the phd finger of ing4 in complex with an h3k4me3 histone peptide
Structure deposition date
2007-04-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
8
% buried
28
Peptide accession
Q9UNL4
Residue number A
212
Residue number B
217
Peptide name
Inhibitor of growth protein 4

Ligandability

Cysteine 212 of Inhibitor of growth protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 217 of Inhibitor of growth protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inhibitor of growth protein 4 between cysteines 201 and 226 (21 and 46 respectively in this structure).

Details

Redox score ?
81
PDB code
1wen
Structure name
solution structure of phd domain in ing1-like protein bac25079
Structure deposition date
2004-05-25
Thiol separation (Å)
3
Half-sphere exposure sum ?
42
Minimum pKa ?
10
% buried
2
Peptide accession
Q8C0D7
Residue number A
201
Residue number B
226
Peptide name
Inhibitor of growth protein 4

Ligandability

Cysteine 201 of Inhibitor of growth protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 226 of Inhibitor of growth protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inhibitor of growth protein 4 between cysteines 199 and 212. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
2k1j
Structure name
plan homeodomain finger of tumour supressor ing4
Structure deposition date
2008-03-05
Thiol separation (Å)
8
Half-sphere exposure sum ?
59
Minimum pKa ?
7
% buried
16
Peptide accession
Q9UNL4
Residue number A
199
Residue number B
212
Peptide name
Inhibitor of growth protein 4

Ligandability

Cysteine 199 of Inhibitor of growth protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 212 of Inhibitor of growth protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inhibitor of growth protein 4 between cysteines 199 and 217. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
2m1r
Structure name
phd domain of ing4 n214d mutant
Structure deposition date
2012-12-05
Thiol separation (Å)
10
Half-sphere exposure sum ?
48
Minimum pKa ?
7
% buried
6
Peptide accession
Q9UNL4
Residue number A
199
Residue number B
217
Peptide name
Inhibitor of growth protein 4

Ligandability

Cysteine 199 of Inhibitor of growth protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 217 of Inhibitor of growth protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inhibitor of growth protein 4 between cysteines 199 and 239 (19 and 59 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
1wen
Structure name
solution structure of phd domain in ing1-like protein bac25079
Structure deposition date
2004-05-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
6
% buried
11
Peptide accession
Q8C0D7
Residue number A
199
Residue number B
239
Peptide name
Inhibitor of growth protein 4

Ligandability

Cysteine 199 of Inhibitor of growth protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 239 of Inhibitor of growth protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inhibitor of growth protein 4 between cysteines 226 and 239. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
2k1j
Structure name
plan homeodomain finger of tumour supressor ing4
Structure deposition date
2008-03-05
Thiol separation (Å)
8
Half-sphere exposure sum ?
56
Minimum pKa ?
10
% buried
15
Peptide accession
Q9UNL4
Residue number A
226
Residue number B
239
Peptide name
Inhibitor of growth protein 4

Ligandability

Cysteine 226 of Inhibitor of growth protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 239 of Inhibitor of growth protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inhibitor of growth protein 4 between cysteines 212 and 226. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
2k1j
Structure name
plan homeodomain finger of tumour supressor ing4
Structure deposition date
2008-03-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
54
Minimum pKa ?
10
% buried
15
Peptide accession
Q9UNL4
Residue number A
212
Residue number B
226
Peptide name
Inhibitor of growth protein 4

Ligandability

Cysteine 212 of Inhibitor of growth protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 226 of Inhibitor of growth protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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