ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Probable dimethyladenosine transferase

Intramolecular
Cysteine 84 and cysteine 125
Cysteine 125 and cysteine 150
A redox-regulated disulphide may form within Probable dimethyladenosine transferase between cysteines 84 and 125. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
6w6c
Structure name
structural and catalytic roles of human 18s rrna methyltransferases dimt1 in ribosome assembly and translation
Structure deposition date
2020-03-16
Thiol separation (Å)
8
Half-sphere exposure sum ?
85
Minimum pKa ?
11
% buried
85
Peptide accession
Q9UNQ2
Residue number A
84
Residue number B
125
Peptide name
Probable dimethyladenosine transferase

Ligandability

Cysteine 84 of Probable dimethyladenosine transferase

Cysteine 125 of Probable dimethyladenosine transferase

A redox-regulated disulphide may form within Probable dimethyladenosine transferase between cysteines 125 and 150. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
6w6f
Structure name
structural and catalytic roles of human 18s rrna methyltransferases dimt1 in ribosome assembly and translation
Structure deposition date
2020-03-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
85
Minimum pKa ?
11
% buried
84
Peptide accession
Q9UNQ2
Residue number A
125
Residue number B
150
Peptide name
Probable dimethyladenosine transferase

Ligandability

Cysteine 125 of Probable dimethyladenosine transferase

Cysteine 150 of Probable dimethyladenosine transferase

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