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Solute carrier family 12 member 4

Intermolecular
Cysteine 781 and cysteine 781
Intramolecular
Cysteine 343 and cysteine 353
Cysteine 163 and cysteine 626
Cysteine 308 and cysteine 323
Cysteine 161 and cysteine 162
Cysteine 160 and cysteine 161
Cysteine 204 and cysteine 588
Cysteine 162 and cysteine 163
Cysteine 160 and cysteine 163
Cysteine 162 and cysteine 626
More...
Cysteine 160 and cysteine 162
Cysteine 762 and cysteine 781
Cysteine 161 and cysteine 163
Cysteine 160 and cysteine 626
Cysteine 163 and cysteine 588
A redox-regulated disulphide may form between two units of Solute carrier family 12 member 4 at cysteines 781 and 781. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
7air
Structure name
structure of human potassium chloride transporter kcc1 in nacl (subclass 2)
Structure deposition date
2020-09-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
90
Minimum pKa ?
12
% buried
100
Peptide A name
Solute carrier family 12 member 4
Peptide B name
Solute carrier family 12 member 4
Peptide A accession
Q9UP95
Peptide B accession
Q9UP95
Peptide A residue number
781
Peptide B residue number
781

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Solute carrier family 12 member 4 between cysteines 343 and 353.

Details

Redox score ?
87
PDB code
7aip
Structure name
structure of human potassium chloride transporter kcc1 in nacl (reference map)
Structure deposition date
2020-09-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UP95
Residue number A
343
Residue number B
353
Peptide name
Solute carrier family 12 member 4

Ligandability

Cysteine 343 of Solute carrier family 12 member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 353 of Solute carrier family 12 member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Solute carrier family 12 member 4 between cysteines 163 and 626.

Details

Redox score ?
82
PDB code
7air
Structure name
structure of human potassium chloride transporter kcc1 in nacl (subclass 2)
Structure deposition date
2020-09-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UP95
Residue number A
163
Residue number B
626
Peptide name
Solute carrier family 12 member 4

Ligandability

Cysteine 163 of Solute carrier family 12 member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 626 of Solute carrier family 12 member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Solute carrier family 12 member 4 between cysteines 308 and 323.

Details

Redox score ?
81
PDB code
6kkt
Structure name
human kcc1 structure determined in kcl and lipid nanodisc
Structure deposition date
2019-07-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UP95
Residue number A
308
Residue number B
323
Peptide name
Solute carrier family 12 member 4

Ligandability

Cysteine 308 of Solute carrier family 12 member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 323 of Solute carrier family 12 member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Solute carrier family 12 member 4 between cysteines 161 and 162. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
7tth
Structure name
human potassium-chloride cotransporter 1 in inward-open state
Structure deposition date
2022-02-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
47
Peptide accession
Q9UP95
Residue number A
161
Residue number B
162
Peptide name
Solute carrier family 12 member 4

Ligandability

Cysteine 161 of Solute carrier family 12 member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 162 of Solute carrier family 12 member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Solute carrier family 12 member 4 between cysteines 160 and 161. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
6kku
Structure name
human kcc1 structure determined in nacl and gdn
Structure deposition date
2019-07-27
Thiol separation (Å)
7
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
88
Peptide accession
Q9UP95
Residue number A
160
Residue number B
161
Peptide name
Solute carrier family 12 member 4

Ligandability

Cysteine 160 of Solute carrier family 12 member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 161 of Solute carrier family 12 member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Solute carrier family 12 member 4 between cysteines 204 and 588. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
7air
Structure name
structure of human potassium chloride transporter kcc1 in nacl (subclass 2)
Structure deposition date
2020-09-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
84
Minimum pKa ?
11
% buried
94
Peptide accession
Q9UP95
Residue number A
204
Residue number B
588
Peptide name
Solute carrier family 12 member 4

Ligandability

Cysteine 204 of Solute carrier family 12 member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 588 of Solute carrier family 12 member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Solute carrier family 12 member 4 between cysteines 162 and 163. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
7tti
Structure name
human kcc1 bound with vu0463271 in an outward-open state
Structure deposition date
2022-02-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
70
Minimum pKa ?
10
% buried
nan
Peptide accession
Q9UP95
Residue number A
162
Residue number B
163
Peptide name
Solute carrier family 12 member 4

Ligandability

Cysteine 162 of Solute carrier family 12 member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 163 of Solute carrier family 12 member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Solute carrier family 12 member 4 between cysteines 160 and 163. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6kku
Structure name
human kcc1 structure determined in nacl and gdn
Structure deposition date
2019-07-27
Thiol separation (Å)
8
Half-sphere exposure sum ?
82
Minimum pKa ?
13
% buried
nan
Peptide accession
Q9UP95
Residue number A
160
Residue number B
163
Peptide name
Solute carrier family 12 member 4

Ligandability

Cysteine 160 of Solute carrier family 12 member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 163 of Solute carrier family 12 member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Solute carrier family 12 member 4 between cysteines 162 and 626. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
7tth
Structure name
human potassium-chloride cotransporter 1 in inward-open state
Structure deposition date
2022-02-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
nan
Peptide accession
Q9UP95
Residue number A
162
Residue number B
626
Peptide name
Solute carrier family 12 member 4

Ligandability

Cysteine 162 of Solute carrier family 12 member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 626 of Solute carrier family 12 member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Solute carrier family 12 member 4 between cysteines 160 and 162. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
7aiq
Structure name
structure of human potassium chloride transporter kcc1 in nacl (subclass 1)
Structure deposition date
2020-09-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
62
Peptide accession
Q9UP95
Residue number A
160
Residue number B
162
Peptide name
Solute carrier family 12 member 4

Ligandability

Cysteine 160 of Solute carrier family 12 member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 162 of Solute carrier family 12 member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Solute carrier family 12 member 4 between cysteines 762 and 781. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
7tth
Structure name
human potassium-chloride cotransporter 1 in inward-open state
Structure deposition date
2022-02-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
84
Minimum pKa ?
11
% buried
85
Peptide accession
Q9UP95
Residue number A
762
Residue number B
781
Peptide name
Solute carrier family 12 member 4

Ligandability

Cysteine 762 of Solute carrier family 12 member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 781 of Solute carrier family 12 member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Solute carrier family 12 member 4 between cysteines 161 and 163. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
6kkt
Structure name
human kcc1 structure determined in kcl and lipid nanodisc
Structure deposition date
2019-07-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
81
Minimum pKa ?
12
% buried
nan
Peptide accession
Q9UP95
Residue number A
161
Residue number B
163
Peptide name
Solute carrier family 12 member 4

Ligandability

Cysteine 161 of Solute carrier family 12 member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 163 of Solute carrier family 12 member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Solute carrier family 12 member 4 between cysteines 160 and 626. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
6kku
Structure name
human kcc1 structure determined in nacl and gdn
Structure deposition date
2019-07-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
77
Minimum pKa ?
13
% buried
nan
Peptide accession
Q9UP95
Residue number A
160
Residue number B
626
Peptide name
Solute carrier family 12 member 4

Ligandability

Cysteine 160 of Solute carrier family 12 member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 626 of Solute carrier family 12 member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Solute carrier family 12 member 4 between cysteines 163 and 588. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
24
PDB code
6kkr
Structure name
human kcc1 structure determined in kcl and detergent gdn
Structure deposition date
2019-07-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
84
Minimum pKa ?
14
% buried
nan
Peptide accession
Q9UP95
Residue number A
163
Residue number B
588
Peptide name
Solute carrier family 12 member 4

Ligandability

Cysteine 163 of Solute carrier family 12 member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 588 of Solute carrier family 12 member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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