ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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non-specific serine/threonine protein kinase

Intramolecular
Cysteine 252 and cysteine 319
A redox-regulated disulphide may form within non-specific serine/threonine protein kinase between cysteines 252 and 319 (260 and 327 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
3nuu
Structure name
phosphoinositide-dependent kinase-1 (pdk1) with fragment11
Structure deposition date
2010-07-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
45
Peptide accession
Q9UPJ8
Residue number A
252
Residue number B
319
Peptide name
non-specific serine/threonine protein kinase

Ligandability

Cysteine 252 of non-specific serine/threonine protein kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 319 of non-specific serine/threonine protein kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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