ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

Intramolecular
Cysteine 7133 and cysteine 7135
Cysteine 7133 and cysteine 7188
Cysteine 7135 and cysteine 7188
A redox-regulated disulphide may form within Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 between cysteines 7133 and 7135.

Details

Redox score ?
92
PDB code
5ve9
Structure name
structure of hacf7 ef1-ef2-gar domains
Structure deposition date
2017-04-04
Thiol separation (Å)
3
Half-sphere exposure sum ?
41
Minimum pKa ?
7
% buried
0
Peptide accession
Q9UPN3
Residue number A
7133
Residue number B
7135
Peptide name
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

Ligandability

Cysteine 7133 of Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 7135 of Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 between cysteines 7133 and 7188 (38 and 93 respectively in this structure).

Details

Redox score ?
86
PDB code
5x57
Structure name
structure of gar domain of acf7
Structure deposition date
2017-02-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
7
% buried
0
Peptide accession
Q9UPN3
Residue number A
7133
Residue number B
7188
Peptide name
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

Ligandability

Cysteine 7133 of Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 7188 of Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 between cysteines 7135 and 7188 (40 and 93 respectively in this structure).

Details

Redox score ?
82
PDB code
5x57
Structure name
structure of gar domain of acf7
Structure deposition date
2017-02-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
39
Minimum pKa ?
9
% buried
0
Peptide accession
Q9UPN3
Residue number A
7135
Residue number B
7188
Peptide name
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

Ligandability

Cysteine 7135 of Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 7188 of Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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