ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cystine/glutamate transporter

Intermolecular
Cysteine 210 of 4F2 cell-surface antigen heavy chain and cysteine 158
Intramolecular
Cysteine 197 and cysteine 327
A redox-regulated disulphide may form between cysteine 210 of 4F2 cell-surface antigen heavy chain and cysteine 158 of Cystine/glutamate transporter (211 and 158 respectively in this structure).

Details

Redox score ?
88
PDB code
7epz
Structure name
overall structure of erastin-bound xct-4f2hc complex
Structure deposition date
2021-04-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
40
Minimum pKa ?
nan
% buried
nan
Peptide A name
4F2 cell-surface antigen heavy chain
Peptide B name
Cystine/glutamate transporter
Peptide A accession
J3KPF3
Peptide B accession
Q9UPY5
Peptide A residue number
210
Peptide B residue number
158

Ligandability

Cysteine 210 of 4F2 cell-surface antigen heavy chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 158 of Cystine/glutamate transporter

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cystine/glutamate transporter between cysteines 197 and 327. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7p9u
Structure name
cryo em structure of system xc- in complex with glutamate
Structure deposition date
2021-07-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
70
Peptide accession
Q9UPY5
Residue number A
197
Residue number B
327
Peptide name
Cystine/glutamate transporter

Ligandability

Cysteine 197 of Cystine/glutamate transporter

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 327 of Cystine/glutamate transporter

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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