ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Microtubule-associated protein RP/EB family member 3

Intermolecular
Cysteine 228 of Microtubule-associated protein RP/EB family member 1 and cysteine 237
Intramolecular
Cysteine 45 and cysteine 55
A redox-regulated disulphide may form between cysteine 228 of Microtubule-associated protein RP/EB family member 1 and cysteine 237 of Microtubule-associated protein RP/EB family member 3. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
3tq7
Structure name
eb1c/eb3c heterodimer in complex with the cap-gly domain of p150glued
Structure deposition date
2011-09-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
55
Minimum pKa ?
11
% buried
45
Peptide A name
Microtubule-associated protein RP/EB family member 1
Peptide B name
Microtubule-associated protein RP/EB family member 3
Peptide A accession
Q15691
Peptide B accession
Q9UPY8
Peptide A residue number
228
Peptide B residue number
237

Ligandability

Cysteine 228 of Microtubule-associated protein RP/EB family member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 237 of Microtubule-associated protein RP/EB family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Microtubule-associated protein RP/EB family member 3 between cysteines 45 and 55. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
3co1
Structure name
crystal structure of microtubule binding domain of human eb3
Structure deposition date
2008-03-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
12
% buried
79
Peptide accession
Q9UPY8
Residue number A
45
Residue number B
55
Peptide name
Microtubule-associated protein RP/EB family member 3

Ligandability

Cysteine 45 of Microtubule-associated protein RP/EB family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 55 of Microtubule-associated protein RP/EB family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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