Regulating synaptic membrane exocytosis protein 2
Intermolecular
Cysteine 5 of Protein unc-13 homolog A and cysteine 95
Cysteine 5 of Protein unc-13 homolog A and cysteine 116
Intramolecular
Cysteine 92 and cysteine 95
Cysteine 92 and cysteine 119
Cysteine 108 and cysteine 111
Cysteine 92 and cysteine 116
Cysteine 108 and cysteine 137
Cysteine 108 and cysteine 134
Cysteine 111 and cysteine 137
Cysteine 95 and cysteine 119
More...Cysteine 111 and cysteine 134
Cysteine 95 and cysteine 116
Cysteine 134 and cysteine 137
Cysteine 116 and cysteine 119
Cysteine 92 and cysteine 134
Cysteine 119 and cysteine 134
2cjs A 5 C 95
A redox-regulated disulphide may form between cysteine 5 of Protein unc-13 homolog A and cysteine 95 of Regulating synaptic membrane exocytosis protein 2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
2cjs
Structure name
structural basis for a munc13-1 homodimer - munc13-1 - rim heterodimer switch: c2-domains as versatile protein-protein interaction modules
Structure deposition date
2006-04-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
7
% buried
57
Peptide A name
Protein unc-13 homolog A
Peptide B name
Regulating synaptic membrane exocytosis protein 2
Peptide A accession
Q62768
Peptide B accession
Q9JIS1
Peptide A residue number
5
Peptide B residue number
95
Ligandability
Cysteine 5 of Protein unc-13 homolog A
Cysteine 95 of Regulating synaptic membrane exocytosis protein 2
2cjs A 5 C 116
A redox-regulated disulphide may form between cysteine 5 of Protein unc-13 homolog A and cysteine 116 of Regulating synaptic membrane exocytosis protein 2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
2cjs
Structure name
structural basis for a munc13-1 homodimer - munc13-1 - rim heterodimer switch: c2-domains as versatile protein-protein interaction modules
Structure deposition date
2006-04-06
Thiol separation (Å)
8
Half-sphere exposure sum ?
82
Minimum pKa ?
12
% buried
74
Peptide A name
Protein unc-13 homolog A
Peptide B name
Regulating synaptic membrane exocytosis protein 2
Peptide A accession
Q62768
Peptide B accession
Q9JIS1
Peptide A residue number
5
Peptide B residue number
116
Ligandability
Cysteine 5 of Protein unc-13 homolog A
Cysteine 116 of Regulating synaptic membrane exocytosis protein 2
2cjs C 92 C 95
A redox-regulated disulphide may form within Regulating synaptic membrane exocytosis protein 2 between cysteines 92 and 95.
Details
Redox score ?
91
PDB code
2cjs
Structure name
structural basis for a munc13-1 homodimer - munc13-1 - rim heterodimer switch: c2-domains as versatile protein-protein interaction modules
Structure deposition date
2006-04-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
3
% buried
41
Peptide accession
Q9JIS1
Residue number A
92
Residue number B
95
Peptide name
Regulating synaptic membrane exocytosis protein 2
Ligandability
Cysteine 92 of Regulating synaptic membrane exocytosis protein 2
Cysteine 95 of Regulating synaptic membrane exocytosis protein 2
2cjs C 92 C 119
A redox-regulated disulphide may form within Regulating synaptic membrane exocytosis protein 2 between cysteines 92 and 119.
Details
Redox score ?
89
PDB code
2cjs
Structure name
structural basis for a munc13-1 homodimer - munc13-1 - rim heterodimer switch: c2-domains as versatile protein-protein interaction modules
Structure deposition date
2006-04-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
3
% buried
44
Peptide accession
Q9JIS1
Residue number A
92
Residue number B
119
Peptide name
Regulating synaptic membrane exocytosis protein 2
Ligandability
Cysteine 92 of Regulating synaptic membrane exocytosis protein 2
Cysteine 119 of Regulating synaptic membrane exocytosis protein 2
2cjs C 108 C 111
A redox-regulated disulphide may form within Regulating synaptic membrane exocytosis protein 2 between cysteines 108 and 111.
Details
Redox score ?
87
PDB code
2cjs
Structure name
structural basis for a munc13-1 homodimer - munc13-1 - rim heterodimer switch: c2-domains as versatile protein-protein interaction modules
Structure deposition date
2006-04-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
3
% buried
48
Peptide accession
Q9JIS1
Residue number A
108
Residue number B
111
Peptide name
Regulating synaptic membrane exocytosis protein 2
Ligandability
Cysteine 108 of Regulating synaptic membrane exocytosis protein 2
Cysteine 111 of Regulating synaptic membrane exocytosis protein 2
2cjs C 92 C 116
A redox-regulated disulphide may form within Regulating synaptic membrane exocytosis protein 2 between cysteines 92 and 116.
Details
Redox score ?
87
PDB code
2cjs
Structure name
structural basis for a munc13-1 homodimer - munc13-1 - rim heterodimer switch: c2-domains as versatile protein-protein interaction modules
Structure deposition date
2006-04-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
76
Minimum pKa ?
3
% buried
58
Peptide accession
Q9JIS1
Residue number A
92
Residue number B
116
Peptide name
Regulating synaptic membrane exocytosis protein 2
Ligandability
Cysteine 92 of Regulating synaptic membrane exocytosis protein 2
Cysteine 116 of Regulating synaptic membrane exocytosis protein 2
2cjs C 108 C 137
A redox-regulated disulphide may form within Regulating synaptic membrane exocytosis protein 2 between cysteines 108 and 137.
Details
Redox score ?
86
PDB code
2cjs
Structure name
structural basis for a munc13-1 homodimer - munc13-1 - rim heterodimer switch: c2-domains as versatile protein-protein interaction modules
Structure deposition date
2006-04-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
3
% buried
53
Peptide accession
Q9JIS1
Residue number A
108
Residue number B
137
Peptide name
Regulating synaptic membrane exocytosis protein 2
Ligandability
Cysteine 108 of Regulating synaptic membrane exocytosis protein 2
Cysteine 137 of Regulating synaptic membrane exocytosis protein 2
2cjs C 108 C 134
A redox-regulated disulphide may form within Regulating synaptic membrane exocytosis protein 2 between cysteines 108 and 134.
Details
Redox score ?
84
PDB code
2cjs
Structure name
structural basis for a munc13-1 homodimer - munc13-1 - rim heterodimer switch: c2-domains as versatile protein-protein interaction modules
Structure deposition date
2006-04-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
3
% buried
56
Peptide accession
Q9JIS1
Residue number A
108
Residue number B
134
Peptide name
Regulating synaptic membrane exocytosis protein 2
Ligandability
Cysteine 108 of Regulating synaptic membrane exocytosis protein 2
Cysteine 134 of Regulating synaptic membrane exocytosis protein 2
2cjs C 111 C 137
A redox-regulated disulphide may form within Regulating synaptic membrane exocytosis protein 2 between cysteines 111 and 137.
Details
Redox score ?
78
PDB code
2cjs
Structure name
structural basis for a munc13-1 homodimer - munc13-1 - rim heterodimer switch: c2-domains as versatile protein-protein interaction modules
Structure deposition date
2006-04-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
8
% buried
33
Peptide accession
Q9JIS1
Residue number A
111
Residue number B
137
Peptide name
Regulating synaptic membrane exocytosis protein 2
Ligandability
Cysteine 111 of Regulating synaptic membrane exocytosis protein 2
Cysteine 137 of Regulating synaptic membrane exocytosis protein 2
2cjs C 95 C 119
A redox-regulated disulphide may form within Regulating synaptic membrane exocytosis protein 2 between cysteines 95 and 119.
Details
Redox score ?
78
PDB code
2cjs
Structure name
structural basis for a munc13-1 homodimer - munc13-1 - rim heterodimer switch: c2-domains as versatile protein-protein interaction modules
Structure deposition date
2006-04-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
7
% buried
40
Peptide accession
Q9JIS1
Residue number A
95
Residue number B
119
Peptide name
Regulating synaptic membrane exocytosis protein 2
Ligandability
Cysteine 95 of Regulating synaptic membrane exocytosis protein 2
Cysteine 119 of Regulating synaptic membrane exocytosis protein 2
2cjs C 111 C 134
A redox-regulated disulphide may form within Regulating synaptic membrane exocytosis protein 2 between cysteines 111 and 134.
Details
Redox score ?
77
PDB code
2cjs
Structure name
structural basis for a munc13-1 homodimer - munc13-1 - rim heterodimer switch: c2-domains as versatile protein-protein interaction modules
Structure deposition date
2006-04-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
8
% buried
36
Peptide accession
Q9JIS1
Residue number A
111
Residue number B
134
Peptide name
Regulating synaptic membrane exocytosis protein 2
Ligandability
Cysteine 111 of Regulating synaptic membrane exocytosis protein 2
Cysteine 134 of Regulating synaptic membrane exocytosis protein 2
2cjs C 95 C 116
A redox-regulated disulphide may form within Regulating synaptic membrane exocytosis protein 2 between cysteines 95 and 116.
Details
Redox score ?
76
PDB code
2cjs
Structure name
structural basis for a munc13-1 homodimer - munc13-1 - rim heterodimer switch: c2-domains as versatile protein-protein interaction modules
Structure deposition date
2006-04-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
7
% buried
54
Peptide accession
Q9JIS1
Residue number A
95
Residue number B
116
Peptide name
Regulating synaptic membrane exocytosis protein 2
Ligandability
Cysteine 95 of Regulating synaptic membrane exocytosis protein 2
Cysteine 116 of Regulating synaptic membrane exocytosis protein 2
2cjs C 134 C 137
A redox-regulated disulphide may form within Regulating synaptic membrane exocytosis protein 2 between cysteines 134 and 137.
Details
Redox score ?
70
PDB code
2cjs
Structure name
structural basis for a munc13-1 homodimer - munc13-1 - rim heterodimer switch: c2-domains as versatile protein-protein interaction modules
Structure deposition date
2006-04-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
11
% buried
42
Peptide accession
Q9JIS1
Residue number A
134
Residue number B
137
Peptide name
Regulating synaptic membrane exocytosis protein 2
Ligandability
Cysteine 134 of Regulating synaptic membrane exocytosis protein 2
Cysteine 137 of Regulating synaptic membrane exocytosis protein 2
2cjs C 116 C 119
A redox-regulated disulphide may form within Regulating synaptic membrane exocytosis protein 2 between cysteines 116 and 119.
Details
Redox score ?
67
PDB code
2cjs
Structure name
structural basis for a munc13-1 homodimer - munc13-1 - rim heterodimer switch: c2-domains as versatile protein-protein interaction modules
Structure deposition date
2006-04-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
81
Minimum pKa ?
11
% buried
57
Peptide accession
Q9JIS1
Residue number A
116
Residue number B
119
Peptide name
Regulating synaptic membrane exocytosis protein 2
Ligandability
Cysteine 116 of Regulating synaptic membrane exocytosis protein 2
Cysteine 119 of Regulating synaptic membrane exocytosis protein 2
2cjs C 92 C 134
A redox-regulated disulphide may form within Regulating synaptic membrane exocytosis protein 2 between cysteines 92 and 134.
Details
Redox score ?
62
PDB code
2cjs
Structure name
structural basis for a munc13-1 homodimer - munc13-1 - rim heterodimer switch: c2-domains as versatile protein-protein interaction modules
Structure deposition date
2006-04-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
3
% buried
45
Peptide accession
Q9JIS1
Residue number A
92
Residue number B
134
Peptide name
Regulating synaptic membrane exocytosis protein 2
Ligandability
Cysteine 92 of Regulating synaptic membrane exocytosis protein 2
Cysteine 134 of Regulating synaptic membrane exocytosis protein 2
2cjs C 119 C 134
A redox-regulated disulphide may form within Regulating synaptic membrane exocytosis protein 2 between cysteines 119 and 134. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
2cjs
Structure name
structural basis for a munc13-1 homodimer - munc13-1 - rim heterodimer switch: c2-domains as versatile protein-protein interaction modules
Structure deposition date
2006-04-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
11
% buried
44
Peptide accession
Q9JIS1
Residue number A
119
Residue number B
134
Peptide name
Regulating synaptic membrane exocytosis protein 2
Ligandability
Cysteine 119 of Regulating synaptic membrane exocytosis protein 2
Cysteine 134 of Regulating synaptic membrane exocytosis protein 2
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