ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Contactin-6

Intramolecular
Cysteine 249 and cysteine 297
Cysteine 144 and cysteine 196
A redox-regulated disulphide may form within Contactin-6 between cysteines 249 and 297.

Details

Redox score ?
80
PDB code
5e5u
Structure name
crystal structure of the complex between carbonic anhydrase-like domain of ptprg and immunoglobulin domains 2-3 of cntn6
Structure deposition date
2015-10-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9JMB8
Residue number A
249
Residue number B
297
Peptide name
Contactin-6

Ligandability

Cysteine 249 of Contactin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 297 of Contactin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Contactin-6 between cysteines 144 and 196.

Details

Redox score ?
79
PDB code
5e5u
Structure name
crystal structure of the complex between carbonic anhydrase-like domain of ptprg and immunoglobulin domains 2-3 of cntn6
Structure deposition date
2015-10-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9JMB8
Residue number A
144
Residue number B
196
Peptide name
Contactin-6

Ligandability

Cysteine 144 of Contactin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 196 of Contactin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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