ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Proliferation-associated protein 2G4

Intramolecular
Cysteine 85 and cysteine 87
Cysteine 149 and cysteine 179 L
A redox-regulated disulphide may form within Proliferation-associated protein 2G4 between cysteines 85 and 87. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
6wm8
Structure name
proliferation-associated protein 2g4 (pa2g4)
Structure deposition date
2020-04-20
Thiol separation (Å)
6
Half-sphere exposure sum ?
85
Minimum pKa ?
10
% buried
96
Peptide accession
Q9UQ80
Residue number A
85
Residue number B
87
Peptide name
Proliferation-associated protein 2G4

Ligandability

Cysteine 85 of Proliferation-associated protein 2G4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 87 of Proliferation-associated protein 2G4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proliferation-associated protein 2G4 between cysteines 149 and 179. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
2v6c
Structure name
crystal structure of erbb3 binding protein 1 (ebp1)
Structure deposition date
2007-07-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
88
Minimum pKa ?
12
% buried
90
Peptide accession
P50580
Residue number A
149
Residue number B
179
Peptide name
Proliferation-associated protein 2G4

Ligandability

Cysteine 149 of Proliferation-associated protein 2G4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 179 of Proliferation-associated protein 2G4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: