Exonuclease 1
Intramolecular
Cysteine 203 and cysteine 239
Cysteine 33 and cysteine 59 L
Cysteine 42 and cysteine 59
Cysteine 219 and cysteine 224 L
Cysteine 219 and cysteine 239 L
Cysteine 59 and cysteine 144
5v0b Z 203 Z 239
A redox-regulated disulphide may form within Exonuclease 1 between cysteines 203 and 239. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
5v0b
Structure name
crystal structure of human exonuclease 1 exo1 (wt) in complex with 5' recessed-end dna (rix)
Structure deposition date
2017-02-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
62
Minimum pKa ?
11
% buried
52
Peptide accession
Q9UQ84
Residue number A
203
Residue number B
239
Peptide name
Exonuclease 1
Ligandability
Cysteine 203 of Exonuclease 1
Cysteine 239 of Exonuclease 1
5uzv Z 33 Z 59
A redox-regulated disulphide may form within Exonuclease 1 between cysteines 33 and 59. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
5uzv
Structure name
crystal structure of human exonuclease 1 exo1 (wt) in complex with 5' recessed-end dna (ri)
Structure deposition date
2017-02-27
Thiol separation (Å)
8
Half-sphere exposure sum ?
67
Minimum pKa ?
12
% buried
92
Peptide accession
Q9UQ84
Residue number A
33
Residue number B
59
Peptide name
Exonuclease 1
Ligandability
Cysteine 33 of Exonuclease 1
Cysteine 59 of Exonuclease 1
5v05 Z 42 Z 59
A redox-regulated disulphide may form within Exonuclease 1 between cysteines 42 and 59. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
5v05
Structure name
crystal structure of human exonuclease 1 exo1 (wt) in complex with 5' recessed-end dna (riii)
Structure deposition date
2017-02-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
78
Peptide accession
Q9UQ84
Residue number A
42
Residue number B
59
Peptide name
Exonuclease 1
Ligandability
Cysteine 42 of Exonuclease 1
Cysteine 59 of Exonuclease 1
5v06 Z 219 Z 224
A redox-regulated disulphide may form within Exonuclease 1 between cysteines 219 and 224. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
5v06
Structure name
crystal structure of human exonuclease 1 exo1 (wt) in complex with 5' recessed-end dna (riv)
Structure deposition date
2017-02-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
11
% buried
100
Peptide accession
Q9UQ84
Residue number A
219
Residue number B
224
Peptide name
Exonuclease 1
Ligandability
Cysteine 219 of Exonuclease 1
Cysteine 224 of Exonuclease 1
3qe9 Z 219 Z 239
A redox-regulated disulphide may form within Exonuclease 1 between cysteines 219 and 239. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
31
PDB code
3qe9
Structure name
crystal structure of human exonuclease 1 exo1 (d173a) in complex with dna (complex i)
Structure deposition date
2011-01-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
92
Peptide accession
Q9UQ84
Residue number A
219
Residue number B
239
Peptide name
Exonuclease 1
Ligandability
Cysteine 219 of Exonuclease 1
Cysteine 239 of Exonuclease 1
3qeb Z 59 Z 144
A redox-regulated disulphide may form within Exonuclease 1 between cysteines 59 and 144. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
30
PDB code
3qeb
Structure name
crystal structure of human exonuclease 1 exo1 (wt) in complex with dna and mn2+ (complex iii)
Structure deposition date
2011-01-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
88
Peptide accession
Q9UQ84
Residue number A
59
Residue number B
144
Peptide name
Exonuclease 1
Ligandability
Cysteine 59 of Exonuclease 1
Cysteine 144 of Exonuclease 1
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