ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Brain-specific angiogenesis inhibitor 1-associated protein 2

Intermolecular
Cysteine 202 and cysteine 230
Cysteine 195 and cysteine 230
Intramolecular
Cysteine 195 and cysteine 202
A redox-regulated disulphide may form between two units of Brain-specific angiogenesis inhibitor 1-associated protein 2 at cysteines 202 and 230.

Details

Redox score ?
76
PDB code
1y2o
Structure name
structure of n-terminal domain irsp53/baiap2
Structure deposition date
2004-11-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
7
% buried
57
Peptide A name
Brain-specific angiogenesis inhibitor 1-associated protein 2
Peptide B name
Brain-specific angiogenesis inhibitor 1-associated protein 2
Peptide A accession
Q9UQB8
Peptide B accession
Q9UQB8
Peptide A residue number
202
Peptide B residue number
230

Ligandability

Cysteine 202 of Brain-specific angiogenesis inhibitor 1-associated protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 230 of Brain-specific angiogenesis inhibitor 1-associated protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Brain-specific angiogenesis inhibitor 1-associated protein 2 at cysteines 195 and 230.

Details

Redox score ?
68
PDB code
1y2o
Structure name
structure of n-terminal domain irsp53/baiap2
Structure deposition date
2004-11-23
Thiol separation (Å)
6
Half-sphere exposure sum ?
67
Minimum pKa ?
7
% buried
52
Peptide A name
Brain-specific angiogenesis inhibitor 1-associated protein 2
Peptide B name
Brain-specific angiogenesis inhibitor 1-associated protein 2
Peptide A accession
Q9UQB8
Peptide B accession
Q9UQB8
Peptide A residue number
195
Peptide B residue number
230

Ligandability

Cysteine 195 of Brain-specific angiogenesis inhibitor 1-associated protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 230 of Brain-specific angiogenesis inhibitor 1-associated protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Brain-specific angiogenesis inhibitor 1-associated protein 2 between cysteines 195 and 202. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
1wdz
Structure name
crystal structure of rcb domain of irsp53
Structure deposition date
2004-05-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
11
% buried
50
Peptide accession
Q9UQB8
Residue number A
195
Residue number B
202
Peptide name
Brain-specific angiogenesis inhibitor 1-associated protein 2

Ligandability

Cysteine 195 of Brain-specific angiogenesis inhibitor 1-associated protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 202 of Brain-specific angiogenesis inhibitor 1-associated protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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