Sodium channel protein type 8 subunit alpha
Intermolecular
Cysteine 1191 and cysteine 181 of Sodium channel subunit beta-1
Intramolecular
Cysteine 906 and cysteine 912
Cysteine 1721 and cysteine 1736
Cysteine 1356 and cysteine 1376
Cysteine 944 and cysteine 953
Cysteine 281 and cysteine 333
Cysteine 324 and cysteine 339
Cysteine 281 and cysteine 339
Cysteine 281 and cysteine 324
Cysteine 333 and cysteine 339
More...Cysteine 324 and cysteine 333
Cysteine 1567 and cysteine 1569
Cysteine 904 and cysteine 906
8fhd A 1191 C 181
A redox-regulated disulphide may form between cysteine 1191 of Sodium channel protein type 8 subunit alpha and cysteine 181 of Sodium channel subunit beta-1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
8fhd
Structure name
cryo-em structure of human voltage-gated sodium channel nav1
Structure deposition date
2022-12-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
42
Peptide A name
Sodium channel protein type 8 subunit alpha
Peptide B name
Sodium channel subunit beta-1
Peptide A accession
Q9UQD0
Peptide B accession
Q07699
Peptide A residue number
1191
Peptide B residue number
181
Ligandability
Cysteine 1191 of Sodium channel protein type 8 subunit alpha
Cysteine 181 of Sodium channel subunit beta-1
8fhd A 906 A 912
A redox-regulated disulphide may form within Sodium channel protein type 8 subunit alpha between cysteines 906 and 912.
Details
Redox score ?
87
PDB code
8fhd
Structure name
cryo-em structure of human voltage-gated sodium channel nav1
Structure deposition date
2022-12-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
32
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UQD0
Residue number A
906
Residue number B
912
Peptide name
Sodium channel protein type 8 subunit alpha
Ligandability
Cysteine 906 of Sodium channel protein type 8 subunit alpha
Cysteine 912 of Sodium channel protein type 8 subunit alpha
8fhd A 1721 A 1736
A redox-regulated disulphide may form within Sodium channel protein type 8 subunit alpha between cysteines 1721 and 1736.
Details
Redox score ?
85
PDB code
8fhd
Structure name
cryo-em structure of human voltage-gated sodium channel nav1
Structure deposition date
2022-12-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UQD0
Residue number A
1721
Residue number B
1736
Peptide name
Sodium channel protein type 8 subunit alpha
Ligandability
Cysteine 1721 of Sodium channel protein type 8 subunit alpha
Cysteine 1736 of Sodium channel protein type 8 subunit alpha
8fhd A 1356 A 1376
A redox-regulated disulphide may form within Sodium channel protein type 8 subunit alpha between cysteines 1356 and 1376.
Details
Redox score ?
85
PDB code
8fhd
Structure name
cryo-em structure of human voltage-gated sodium channel nav1
Structure deposition date
2022-12-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UQD0
Residue number A
1356
Residue number B
1376
Peptide name
Sodium channel protein type 8 subunit alpha
Ligandability
Cysteine 1356 of Sodium channel protein type 8 subunit alpha
Cysteine 1376 of Sodium channel protein type 8 subunit alpha
8fhd A 944 A 953
A redox-regulated disulphide may form within Sodium channel protein type 8 subunit alpha between cysteines 944 and 953.
Details
Redox score ?
84
PDB code
8fhd
Structure name
cryo-em structure of human voltage-gated sodium channel nav1
Structure deposition date
2022-12-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UQD0
Residue number A
944
Residue number B
953
Peptide name
Sodium channel protein type 8 subunit alpha
Ligandability
Cysteine 944 of Sodium channel protein type 8 subunit alpha
Cysteine 953 of Sodium channel protein type 8 subunit alpha
8fhd A 281 A 333
A redox-regulated disulphide may form within Sodium channel protein type 8 subunit alpha between cysteines 281 and 333.
Details
Redox score ?
82
PDB code
8fhd
Structure name
cryo-em structure of human voltage-gated sodium channel nav1
Structure deposition date
2022-12-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UQD0
Residue number A
281
Residue number B
333
Peptide name
Sodium channel protein type 8 subunit alpha
Ligandability
Cysteine 281 of Sodium channel protein type 8 subunit alpha
Cysteine 333 of Sodium channel protein type 8 subunit alpha
8fhd A 324 A 339
A redox-regulated disulphide may form within Sodium channel protein type 8 subunit alpha between cysteines 324 and 339.
Details
Redox score ?
81
PDB code
8fhd
Structure name
cryo-em structure of human voltage-gated sodium channel nav1
Structure deposition date
2022-12-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UQD0
Residue number A
324
Residue number B
339
Peptide name
Sodium channel protein type 8 subunit alpha
Ligandability
Cysteine 324 of Sodium channel protein type 8 subunit alpha
Cysteine 339 of Sodium channel protein type 8 subunit alpha
8fhd A 281 A 339
A redox-regulated disulphide may form within Sodium channel protein type 8 subunit alpha between cysteines 281 and 339.
Details
Redox score ?
73
PDB code
8fhd
Structure name
cryo-em structure of human voltage-gated sodium channel nav1
Structure deposition date
2022-12-14
Thiol separation (Å)
3
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UQD0
Residue number A
281
Residue number B
339
Peptide name
Sodium channel protein type 8 subunit alpha
Ligandability
Cysteine 281 of Sodium channel protein type 8 subunit alpha
Cysteine 339 of Sodium channel protein type 8 subunit alpha
8fhd A 281 A 324
A redox-regulated disulphide may form within Sodium channel protein type 8 subunit alpha between cysteines 281 and 324.
Details
Redox score ?
71
PDB code
8fhd
Structure name
cryo-em structure of human voltage-gated sodium channel nav1
Structure deposition date
2022-12-14
Thiol separation (Å)
3
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UQD0
Residue number A
281
Residue number B
324
Peptide name
Sodium channel protein type 8 subunit alpha
Ligandability
Cysteine 281 of Sodium channel protein type 8 subunit alpha
Cysteine 324 of Sodium channel protein type 8 subunit alpha
8fhd A 333 A 339
A redox-regulated disulphide may form within Sodium channel protein type 8 subunit alpha between cysteines 333 and 339.
Details
Redox score ?
71
PDB code
8fhd
Structure name
cryo-em structure of human voltage-gated sodium channel nav1
Structure deposition date
2022-12-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UQD0
Residue number A
333
Residue number B
339
Peptide name
Sodium channel protein type 8 subunit alpha
Ligandability
Cysteine 333 of Sodium channel protein type 8 subunit alpha
Cysteine 339 of Sodium channel protein type 8 subunit alpha
8fhd A 324 A 333
A redox-regulated disulphide may form within Sodium channel protein type 8 subunit alpha between cysteines 324 and 333.
Details
Redox score ?
66
PDB code
8fhd
Structure name
cryo-em structure of human voltage-gated sodium channel nav1
Structure deposition date
2022-12-14
Thiol separation (Å)
5
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UQD0
Residue number A
324
Residue number B
333
Peptide name
Sodium channel protein type 8 subunit alpha
Ligandability
Cysteine 324 of Sodium channel protein type 8 subunit alpha
Cysteine 333 of Sodium channel protein type 8 subunit alpha
8fhd A 1567 A 1569
A redox-regulated disulphide may form within Sodium channel protein type 8 subunit alpha between cysteines 1567 and 1569. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
8fhd
Structure name
cryo-em structure of human voltage-gated sodium channel nav1
Structure deposition date
2022-12-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
41
Minimum pKa ?
9
% buried
29
Peptide accession
Q9UQD0
Residue number A
1567
Residue number B
1569
Peptide name
Sodium channel protein type 8 subunit alpha
Ligandability
Cysteine 1567 of Sodium channel protein type 8 subunit alpha
Cysteine 1569 of Sodium channel protein type 8 subunit alpha
8fhd A 904 A 906
A redox-regulated disulphide may form within Sodium channel protein type 8 subunit alpha between cysteines 904 and 906. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
8fhd
Structure name
cryo-em structure of human voltage-gated sodium channel nav1
Structure deposition date
2022-12-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
45
Minimum pKa ?
9
% buried
nan
Peptide accession
Q9UQD0
Residue number A
904
Residue number B
906
Peptide name
Sodium channel protein type 8 subunit alpha
Ligandability
Cysteine 904 of Sodium channel protein type 8 subunit alpha
Cysteine 906 of Sodium channel protein type 8 subunit alpha
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