a tool for identifying drug-targetable redox-active disulphides

SH2B adapter protein 3

Intramolecular

Cysteine 422 and cysteine 426

A redox-regulated disulphide may form within SH2B adapter protein 3 between cysteines 422 and 426.

Details

Redox score ?

86

PDB code

Structure name

crystal structure of the lnk sh2 domain in complex with an epor py454 phosphopeptide

Structure deposition date

2021-06-27

Thiol separation (Å)

2

Half-sphere exposure sum ?

32

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

422

Residue number B

426

Peptide name

SH2B adapter protein 3

Ligandability

Cysteine 422 of SH2B adapter protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 426 of SH2B adapter protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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