ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Lysosome-associated membrane glycoprotein 3

Intramolecular
Cysteine 339 and cysteine 376
Cysteine 237 and cysteine 274
A redox-regulated disulphide may form within Lysosome-associated membrane glycoprotein 3 between cysteines 339 and 376.

Details

Redox score ?
83
PDB code
4akm
Structure name
crystal structure of the human lysosome-associated membrane protein lamp-3 (aka dc-lamp)
Structure deposition date
2012-02-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UQV4
Residue number A
339
Residue number B
376
Peptide name
Lysosome-associated membrane glycoprotein 3

Ligandability

Cysteine 339 of Lysosome-associated membrane glycoprotein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 376 of Lysosome-associated membrane glycoprotein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lysosome-associated membrane glycoprotein 3 between cysteines 237 and 274.

Details

Redox score ?
82
PDB code
4akm
Structure name
crystal structure of the human lysosome-associated membrane protein lamp-3 (aka dc-lamp)
Structure deposition date
2012-02-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UQV4
Residue number A
237
Residue number B
274
Peptide name
Lysosome-associated membrane glycoprotein 3

Ligandability

Cysteine 237 of Lysosome-associated membrane glycoprotein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 274 of Lysosome-associated membrane glycoprotein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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