ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Short transient receptor potential channel 6

Intramolecular
Cysteine 255 and cysteine 258
Cysteine 253 and cysteine 258
Cysteine 253 and cysteine 255
Cysteine 324 and cysteine 335
A redox-regulated disulphide may form within Short transient receptor potential channel 6 between cysteines 255 and 258.

Details

Redox score ?
85
PDB code
7dxg
Structure name
structure of sar7334-bound trpc6 at 2
Structure deposition date
2021-01-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
35
Minimum pKa ?
6
% buried
4
Peptide accession
Q9Y210
Residue number A
255
Residue number B
258
Peptide name
Short transient receptor potential channel 6

Ligandability

Cysteine 255 of Short transient receptor potential channel 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 258 of Short transient receptor potential channel 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Short transient receptor potential channel 6 between cysteines 253 and 258.

Details

Redox score ?
78
PDB code
7dxg
Structure name
structure of sar7334-bound trpc6 at 2
Structure deposition date
2021-01-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
36
Minimum pKa ?
9
% buried
4
Peptide accession
Q9Y210
Residue number A
253
Residue number B
258
Peptide name
Short transient receptor potential channel 6

Ligandability

Cysteine 253 of Short transient receptor potential channel 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 258 of Short transient receptor potential channel 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Short transient receptor potential channel 6 between cysteines 253 and 255.

Details

Redox score ?
75
PDB code
6uza
Structure name
cryo-em structure of human trpc6 in complex with antagonist am-1473
Structure deposition date
2019-11-14
Thiol separation (Å)
5
Half-sphere exposure sum ?
28
Minimum pKa ?
9
% buried
nan
Peptide accession
Q9Y210
Residue number A
253
Residue number B
255
Peptide name
Short transient receptor potential channel 6

Ligandability

Cysteine 253 of Short transient receptor potential channel 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 255 of Short transient receptor potential channel 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Short transient receptor potential channel 6 between cysteines 324 and 335. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
6cv9
Structure name
cytoplasmic domain of mtrpc6
Structure deposition date
2018-03-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
46
Minimum pKa ?
9
% buried
16
Peptide accession
Q61143
Residue number A
324
Residue number B
335
Peptide name
Short transient receptor potential channel 6

Ligandability

Cysteine 324 of Short transient receptor potential channel 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 335 of Short transient receptor potential channel 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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