ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Protein jagged-2

Intramolecular
Cysteine 317 and cysteine 333
Cysteine 282 and cysteine 293
Cysteine 49 and cysteine 411
Cysteine 249 and cysteine 262 L
Cysteine 311 and cysteine 323
Cysteine 245 and cysteine 256
Cysteine 295 and cysteine 304
Cysteine 211 and cysteine 223
Cysteine 231 and cysteine 240
Cysteine 49 and cysteine 62
More...
Cysteine 276 and cysteine 287
Cysteine 264 and cysteine 273
Cysteine 198 and cysteine 207 L
Cysteine 50 and cysteine 67
Cysteine 74 and cysteine 88
Cysteine 293 and cysteine 304
Cysteine 262 and cysteine 273 L
Cysteine 282 and cysteine 304
Cysteine 249 and cysteine 273 L
Cysteine 317 and cysteine 323
Cysteine 245 and cysteine 249 L
Cysteine 293 and cysteine 295
Cysteine 323 and cysteine 333
Cysteine 262 and cysteine 264 L
Cysteine 311 and cysteine 317
Cysteine 245 and cysteine 262 L
Cysteine 282 and cysteine 295
Cysteine 249 and cysteine 256 L
Cysteine 311 and cysteine 333
Cysteine 50 and cysteine 411
Cysteine 249 and cysteine 264 L
Cysteine 49 and cysteine 50
Cysteine 62 and cysteine 67
Cysteine 50 and cysteine 62
Cysteine 411 and cysteine 67
Cysteine 256 and cysteine 262 L
Cysteine 282 and cysteine 287
Cysteine 287 and cysteine 293
Cysteine 49 and cysteine 67
Cysteine 211 and cysteine 240
A redox-regulated disulphide may form within Protein jagged-2 between cysteines 317 and 333.

Details

Redox score ?
90
PDB code
5mw7
Structure name
human jagged2 c2-egf3
Structure deposition date
2017-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
39
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
317
Residue number B
333
Peptide name
Protein jagged-2

Ligandability

Cysteine 317 of Protein jagged-2

Cysteine 333 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 282 and 293.

Details

Redox score ?
89
PDB code
5mwf
Structure name
human jagged2 c2-egf2
Structure deposition date
2017-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
282
Residue number B
293
Peptide name
Protein jagged-2

Ligandability

Cysteine 282 of Protein jagged-2

Cysteine 293 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 49 and 411 (49 and 62 respectively in this structure).

Details

Redox score ?
88
PDB code
5mw7
Structure name
human jagged2 c2-egf3
Structure deposition date
2017-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
49
Residue number B
411
Peptide name
Protein jagged-2

Ligandability

Cysteine 49 of Protein jagged-2

Cysteine 411 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 249 and 262.

Details

Redox score ?
88
PDB code
5mwf
Structure name
human jagged2 c2-egf2
Structure deposition date
2017-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
249
Residue number B
262
Peptide name
Protein jagged-2

Ligandability

Cysteine 249 of Protein jagged-2

Cysteine 262 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 311 and 323.

Details

Redox score ?
88
PDB code
5mw7
Structure name
human jagged2 c2-egf3
Structure deposition date
2017-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
311
Residue number B
323
Peptide name
Protein jagged-2

Ligandability

Cysteine 311 of Protein jagged-2

Cysteine 323 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 245 and 256.

Details

Redox score ?
87
PDB code
5mw7
Structure name
human jagged2 c2-egf3
Structure deposition date
2017-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
245
Residue number B
256
Peptide name
Protein jagged-2

Ligandability

Cysteine 245 of Protein jagged-2

Cysteine 256 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 295 and 304.

Details

Redox score ?
87
PDB code
5mwf
Structure name
human jagged2 c2-egf2
Structure deposition date
2017-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
295
Residue number B
304
Peptide name
Protein jagged-2

Ligandability

Cysteine 295 of Protein jagged-2

Cysteine 304 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 211 and 223.

Details

Redox score ?
87
PDB code
5mwf
Structure name
human jagged2 c2-egf2
Structure deposition date
2017-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
211
Residue number B
223
Peptide name
Protein jagged-2

Ligandability

Cysteine 211 of Protein jagged-2

Cysteine 223 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 231 and 240.

Details

Redox score ?
86
PDB code
5mwf
Structure name
human jagged2 c2-egf2
Structure deposition date
2017-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
231
Residue number B
240
Peptide name
Protein jagged-2

Ligandability

Cysteine 231 of Protein jagged-2

Cysteine 240 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 49 and 62.

Details

Redox score ?
86
PDB code
5mwf
Structure name
human jagged2 c2-egf2
Structure deposition date
2017-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
49
Residue number B
62
Peptide name
Protein jagged-2

Ligandability

Cysteine 49 of Protein jagged-2

Cysteine 62 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 276 and 287.

Details

Redox score ?
86
PDB code
5mw7
Structure name
human jagged2 c2-egf3
Structure deposition date
2017-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
276
Residue number B
287
Peptide name
Protein jagged-2

Ligandability

Cysteine 276 of Protein jagged-2

Cysteine 287 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 264 and 273.

Details

Redox score ?
86
PDB code
5mwf
Structure name
human jagged2 c2-egf2
Structure deposition date
2017-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
264
Residue number B
273
Peptide name
Protein jagged-2

Ligandability

Cysteine 264 of Protein jagged-2

Cysteine 273 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 198 and 207.

Details

Redox score ?
85
PDB code
5mw5
Structure name
human jagged2 c2-egf2
Structure deposition date
2017-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
198
Residue number B
207
Peptide name
Protein jagged-2

Ligandability

Cysteine 198 of Protein jagged-2

Cysteine 207 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 50 and 67.

Details

Redox score ?
85
PDB code
5mwf
Structure name
human jagged2 c2-egf2
Structure deposition date
2017-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
50
Residue number B
67
Peptide name
Protein jagged-2

Ligandability

Cysteine 50 of Protein jagged-2

Cysteine 67 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 74 and 88.

Details

Redox score ?
84
PDB code
5mw7
Structure name
human jagged2 c2-egf3
Structure deposition date
2017-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
74
Residue number B
88
Peptide name
Protein jagged-2

Ligandability

Cysteine 74 of Protein jagged-2

Cysteine 88 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 293 and 304.

Details

Redox score ?
78
PDB code
5mw7
Structure name
human jagged2 c2-egf3
Structure deposition date
2017-01-18
Thiol separation (Å)
3
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
293
Residue number B
304
Peptide name
Protein jagged-2

Ligandability

Cysteine 293 of Protein jagged-2

Cysteine 304 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 262 and 273.

Details

Redox score ?
77
PDB code
5mwf
Structure name
human jagged2 c2-egf2
Structure deposition date
2017-01-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
262
Residue number B
273
Peptide name
Protein jagged-2

Ligandability

Cysteine 262 of Protein jagged-2

Cysteine 273 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 282 and 304.

Details

Redox score ?
75
PDB code
5mw7
Structure name
human jagged2 c2-egf3
Structure deposition date
2017-01-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
282
Residue number B
304
Peptide name
Protein jagged-2

Ligandability

Cysteine 282 of Protein jagged-2

Cysteine 304 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 249 and 273.

Details

Redox score ?
74
PDB code
5mw7
Structure name
human jagged2 c2-egf3
Structure deposition date
2017-01-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
249
Residue number B
273
Peptide name
Protein jagged-2

Ligandability

Cysteine 249 of Protein jagged-2

Cysteine 273 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 317 and 323.

Details

Redox score ?
73
PDB code
5mw7
Structure name
human jagged2 c2-egf3
Structure deposition date
2017-01-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
42
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
317
Residue number B
323
Peptide name
Protein jagged-2

Ligandability

Cysteine 317 of Protein jagged-2

Cysteine 323 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 245 and 249.

Details

Redox score ?
71
PDB code
5mwf
Structure name
human jagged2 c2-egf2
Structure deposition date
2017-01-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
245
Residue number B
249
Peptide name
Protein jagged-2

Ligandability

Cysteine 245 of Protein jagged-2

Cysteine 249 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 293 and 295.

Details

Redox score ?
70
PDB code
5mw7
Structure name
human jagged2 c2-egf3
Structure deposition date
2017-01-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
293
Residue number B
295
Peptide name
Protein jagged-2

Ligandability

Cysteine 293 of Protein jagged-2

Cysteine 295 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 323 and 333.

Details

Redox score ?
68
PDB code
5mw7
Structure name
human jagged2 c2-egf3
Structure deposition date
2017-01-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
41
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
323
Residue number B
333
Peptide name
Protein jagged-2

Ligandability

Cysteine 323 of Protein jagged-2

Cysteine 333 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 262 and 264.

Details

Redox score ?
67
PDB code
5mwf
Structure name
human jagged2 c2-egf2
Structure deposition date
2017-01-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
262
Residue number B
264
Peptide name
Protein jagged-2

Ligandability

Cysteine 262 of Protein jagged-2

Cysteine 264 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 311 and 317.

Details

Redox score ?
67
PDB code
5mw7
Structure name
human jagged2 c2-egf3
Structure deposition date
2017-01-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
311
Residue number B
317
Peptide name
Protein jagged-2

Ligandability

Cysteine 311 of Protein jagged-2

Cysteine 317 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 245 and 262.

Details

Redox score ?
65
PDB code
5mw5
Structure name
human jagged2 c2-egf2
Structure deposition date
2017-01-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
245
Residue number B
262
Peptide name
Protein jagged-2

Ligandability

Cysteine 245 of Protein jagged-2

Cysteine 262 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 282 and 295.

Details

Redox score ?
65
PDB code
5mw7
Structure name
human jagged2 c2-egf3
Structure deposition date
2017-01-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
282
Residue number B
295
Peptide name
Protein jagged-2

Ligandability

Cysteine 282 of Protein jagged-2

Cysteine 295 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 249 and 256.

Details

Redox score ?
61
PDB code
5mw5
Structure name
human jagged2 c2-egf2
Structure deposition date
2017-01-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
249
Residue number B
256
Peptide name
Protein jagged-2

Ligandability

Cysteine 249 of Protein jagged-2

Cysteine 256 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 311 and 333.

Details

Redox score ?
61
PDB code
5mw7
Structure name
human jagged2 c2-egf3
Structure deposition date
2017-01-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
311
Residue number B
333
Peptide name
Protein jagged-2

Ligandability

Cysteine 311 of Protein jagged-2

Cysteine 333 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 50 and 411 (50 and 62 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
5mw7
Structure name
human jagged2 c2-egf3
Structure deposition date
2017-01-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
50
Residue number B
411
Peptide name
Protein jagged-2

Ligandability

Cysteine 50 of Protein jagged-2

Cysteine 411 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 249 and 264. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
5mwf
Structure name
human jagged2 c2-egf2
Structure deposition date
2017-01-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
249
Residue number B
264
Peptide name
Protein jagged-2

Ligandability

Cysteine 249 of Protein jagged-2

Cysteine 264 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 49 and 50. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
5mwf
Structure name
human jagged2 c2-egf2
Structure deposition date
2017-01-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
49
Residue number B
50
Peptide name
Protein jagged-2

Ligandability

Cysteine 49 of Protein jagged-2

Cysteine 50 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 62 and 67. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
5mwf
Structure name
human jagged2 c2-egf2
Structure deposition date
2017-01-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
62
Residue number B
67
Peptide name
Protein jagged-2

Ligandability

Cysteine 62 of Protein jagged-2

Cysteine 67 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 50 and 62. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
5mwf
Structure name
human jagged2 c2-egf2
Structure deposition date
2017-01-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
50
Residue number B
62
Peptide name
Protein jagged-2

Ligandability

Cysteine 50 of Protein jagged-2

Cysteine 62 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 411 and 67 (62 and 67 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
5mw7
Structure name
human jagged2 c2-egf3
Structure deposition date
2017-01-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
411
Residue number B
67
Peptide name
Protein jagged-2

Ligandability

Cysteine 411 of Protein jagged-2

Cysteine 67 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 256 and 262. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
5mwf
Structure name
human jagged2 c2-egf2
Structure deposition date
2017-01-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
256
Residue number B
262
Peptide name
Protein jagged-2

Ligandability

Cysteine 256 of Protein jagged-2

Cysteine 262 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 282 and 287. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
5mw5
Structure name
human jagged2 c2-egf2
Structure deposition date
2017-01-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
282
Residue number B
287
Peptide name
Protein jagged-2

Ligandability

Cysteine 282 of Protein jagged-2

Cysteine 287 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 287 and 293. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
5mwf
Structure name
human jagged2 c2-egf2
Structure deposition date
2017-01-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
287
Residue number B
293
Peptide name
Protein jagged-2

Ligandability

Cysteine 287 of Protein jagged-2

Cysteine 293 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 49 and 67. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
5mw5
Structure name
human jagged2 c2-egf2
Structure deposition date
2017-01-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
49
Residue number B
67
Peptide name
Protein jagged-2

Ligandability

Cysteine 49 of Protein jagged-2

Cysteine 67 of Protein jagged-2

A redox-regulated disulphide may form within Protein jagged-2 between cysteines 211 and 240. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
5mw5
Structure name
human jagged2 c2-egf2
Structure deposition date
2017-01-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y219
Residue number A
211
Residue number B
240
Peptide name
Protein jagged-2

Ligandability

Cysteine 211 of Protein jagged-2

Cysteine 240 of Protein jagged-2

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