a tool for identifying drug-targetable redox-active disulphides

Cyclin-D-binding Myb-like transcription factor 1

Intramolecular

Cysteine 264 and cysteine 271

A redox-regulated disulphide may form within Cyclin-D-binding Myb-like transcription factor 1 between cysteines 264 and 271. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

51

PDB code

Structure name

solution nmr structure of the n-terminal myb-like 1 domain of the human cyclin-d-binding transcription factor 1 (hdmp1), northeast structural genomics consortium (nesg) target id hr8011a

Structure deposition date

2011-11-10

Thiol separation (Å)

9

Half-sphere exposure sum ?

30

Minimum pK_a ?

9

% buried

8

Peptide accession

Residue number A

264

Residue number B

271

Peptide name

Cyclin-D-binding Myb-like transcription factor 1

Ligandability

Cysteine 264 of Cyclin-D-binding Myb-like transcription factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 271 of Cyclin-D-binding Myb-like transcription factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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