ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Chromodomain Y-like protein

Intramolecular
Cysteine 400 and cysteine 401
Cysteine 485 and cysteine 571
A redox-regulated disulphide may form within Chromodomain Y-like protein between cysteines 400 and 401 (63 and 64 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
2gtr
Structure name
human chromodomain y-like protein
Structure deposition date
2006-04-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
81
Minimum pKa ?
11
% buried
77
Peptide accession
Q9Y232
Residue number A
400
Residue number B
401
Peptide name
Chromodomain Y-like protein

Ligandability

Cysteine 400 of Chromodomain Y-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 401 of Chromodomain Y-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Chromodomain Y-like protein between cysteines 485 and 571 (148 and 234 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
2gtr
Structure name
human chromodomain y-like protein
Structure deposition date
2006-04-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
83
Minimum pKa ?
13
% buried
89
Peptide accession
Q9Y232
Residue number A
485
Residue number B
571
Peptide name
Chromodomain Y-like protein

Ligandability

Cysteine 485 of Chromodomain Y-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 571 of Chromodomain Y-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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