a tool for identifying drug-targetable redox-active disulphides

C->U-editing enzyme APOBEC-2

Intramolecular

Cysteine 128 and cysteine 131

A redox-regulated disulphide may form within C->U-editing enzyme APOBEC-2 between cysteines 128 and 131.

Details

Redox score ?

88

PDB code

Structure name

the apobec2 crystal structure and functional implications for aid

Structure deposition date

2006-11-21

Thiol separation (Å)

4

Half-sphere exposure sum ?

58

Minimum pK_a ?

2

% buried

62

Peptide accession

Residue number A

128

Residue number B

131

Peptide name

C->U-editing enzyme APOBEC-2

Ligandability

Cysteine 128 of C->U-editing enzyme APOBEC-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 131 of C->U-editing enzyme APOBEC-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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