ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Heparanase

Intramolecular
Cysteine 127 and cysteine 179
Cysteine 437 and cysteine 542
A redox-regulated disulphide may form within Heparanase between cysteines 127 and 179.

Details

Redox score ?
82
PDB code
5la7
Structure name
crystal structure of human proheparanase, in complex with glucuronic acid configured aziridine probe jjb355
Structure deposition date
2016-06-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y251
Residue number A
127
Residue number B
179
Peptide name
Heparanase

Ligandability

Cysteine 127 of Heparanase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 179 of Heparanase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Heparanase between cysteines 437 and 542.

Details

Redox score ?
82
PDB code
5l9y
Structure name
crystal structure of human heparanase, in complex with glucuronic acid configured aziridine probe jjb355
Structure deposition date
2016-06-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y251
Residue number A
437
Residue number B
542
Peptide name
Heparanase

Ligandability

Cysteine 437 of Heparanase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 542 of Heparanase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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