DNA polymerase eta
Intramolecular
Cysteine 635 and cysteine 638
Cysteine 384 and cysteine 385
Cysteine 34 and cysteine 72
Cysteine 384 and cysteine 425
Cysteine 212 and cysteine 227
Cysteine 16 and cysteine 34
Cysteine 321 and cysteine 425
3wup A 635 A 638
A redox-regulated disulphide may form within DNA polymerase eta between cysteines 635 and 638.
Details
Redox score ?
91
PDB code
3wup
Structure name
crystal structure of the ubiquitin-binding zinc finger (ubz) domain of the human dna polymerase eta
Structure deposition date
2014-05-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
36
Minimum pKa ?
5
% buried
0
Peptide accession
Q9Y253
Residue number A
635
Residue number B
638
Peptide name
DNA polymerase eta
Ligandability
Cysteine 635 of DNA polymerase eta
Cysteine 638 of DNA polymerase eta
6pl7 A 384 A 385
A redox-regulated disulphide may form within DNA polymerase eta between cysteines 384 and 385. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
6pl7
Structure name
structure of human dna polymerase eta complexed with a in the template base paired with incoming non-hydrolyzable ttp
Structure deposition date
2019-06-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
53
Minimum pKa ?
10
% buried
42
Peptide accession
Q9Y253
Residue number A
384
Residue number B
385
Peptide name
DNA polymerase eta
Ligandability
Cysteine 384 of DNA polymerase eta
Cysteine 385 of DNA polymerase eta
6m7o A 34 A 72
A redox-regulated disulphide may form within DNA polymerase eta between cysteines 34 and 72. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
6m7o
Structure name
human dna polymerase eta ternary complex with mn2+ and dtmpnpp oppositing cda
Structure deposition date
2018-08-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
10
% buried
38
Peptide accession
Q9Y253
Residue number A
34
Residue number B
72
Peptide name
DNA polymerase eta
Ligandability
Cysteine 34 of DNA polymerase eta
Cysteine 72 of DNA polymerase eta
7u7l A 384 A 425
A redox-regulated disulphide may form within DNA polymerase eta between cysteines 384 and 425. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
7u7l
Structure name
human dna polymerase eta-dna ternary mismatch complex:reaction with 1
Structure deposition date
2022-03-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
66
Peptide accession
Q9Y253
Residue number A
384
Residue number B
425
Peptide name
DNA polymerase eta
Ligandability
Cysteine 384 of DNA polymerase eta
Cysteine 425 of DNA polymerase eta
7u7l A 212 A 227
A redox-regulated disulphide may form within DNA polymerase eta between cysteines 212 and 227. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
7u7l
Structure name
human dna polymerase eta-dna ternary mismatch complex:reaction with 1
Structure deposition date
2022-03-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
100
Peptide accession
Q9Y253
Residue number A
212
Residue number B
227
Peptide name
DNA polymerase eta
Ligandability
Cysteine 212 of DNA polymerase eta
Cysteine 227 of DNA polymerase eta
5dga A 16 A 34
A redox-regulated disulphide may form within DNA polymerase eta between cysteines 16 and 34. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
5dga
Structure name
crystal structure of human dna polymerase eta extending an 1,n6- ethenodeoxyadenosine : dt pair by inserting dtmpnpp opposite template da
Structure deposition date
2015-08-27
Thiol separation (Å)
8
Half-sphere exposure sum ?
79
Minimum pKa ?
11
% buried
84
Peptide accession
Q9Y253
Residue number A
16
Residue number B
34
Peptide name
DNA polymerase eta
Ligandability
Cysteine 16 of DNA polymerase eta
Cysteine 34 of DNA polymerase eta
5dg7 A 321 A 425
A redox-regulated disulphide may form within DNA polymerase eta between cysteines 321 and 425. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
5dg7
Structure name
crystal structure of human dna polymerase eta inserting dttp across a dna template containing 1,n6-ethenodeoxyadenosine lesion
Structure deposition date
2015-08-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
12
% buried
100
Peptide accession
Q9Y253
Residue number A
321
Residue number B
425
Peptide name
DNA polymerase eta
Ligandability
Cysteine 321 of DNA polymerase eta
Cysteine 425 of DNA polymerase eta
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