Tumor necrosis factor ligand superfamily member 13B

Intermolecular

Intramolecular

A redox-regulated disulphide may form between two units of Tumor necrosis factor ligand superfamily member 13B at cysteines 245 and 245. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

6fxn

Structure name

crystal structure of human baff in complex with fab fragment of anti- baff antibody belimumab

Structure deposition date

2018-03-09

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide A name

Tumor necrosis factor ligand superfamily member 13B

Peptide B name

Tumor necrosis factor ligand superfamily member 13B

Peptide A accession

Q9Y275

Peptide B accession

Q9Y275

Peptide A residue number

245

Peptide B residue number

245

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Tumor necrosis factor ligand superfamily member 13B at cysteines 232 and 232. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

6fxn

Structure name

crystal structure of human baff in complex with fab fragment of anti- baff antibody belimumab

Structure deposition date

2018-03-09

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide A name

Tumor necrosis factor ligand superfamily member 13B

Peptide B name

Tumor necrosis factor ligand superfamily member 13B

Peptide A accession

Q9Y275

Peptide B accession

Q9Y275

Peptide A residue number

232

Peptide B residue number

232

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor ligand superfamily member 13B between cysteines 232 and 245 (91 and 104 respectively in this structure).