F-box/WD repeat-containing protein 1A
Intermolecular
Cysteine 137 and cysteine 137
Intramolecular
Cysteine 308 and cysteine 511
Cysteine 298 and cysteine 335
Cysteine 308 and cysteine 471
Cysteine 471 and cysteine 511
Cysteine 308 and cysteine 348
Cysteine 348 and cysteine 511
Cysteine 348 and cysteine 399
Cysteine 348 and cysteine 471
2p64 A 137 B 137
A redox-regulated disulphide may form between two units of F-box/WD repeat-containing protein 1A at cysteines 137 and 137.
Details
Redox score ?
77
PDB code
2p64
Structure name
d domain of b-trcp
Structure deposition date
2007-03-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
8
% buried
66
Peptide A name
F-box/WD repeat-containing protein 1A
Peptide B name
F-box/WD repeat-containing protein 1A
Peptide A accession
Q9Y297
Peptide B accession
Q9Y297
Peptide A residue number
137
Peptide B residue number
137
Ligandability
6ttu T 308 T 511
A redox-regulated disulphide may form within F-box/WD repeat-containing protein 1A between cysteines 308 and 511. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
6ttu
Structure name
ubiquitin ligation to substrate by a cullin-ring e3 ligase at 3
Structure deposition date
2019-12-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
91
Minimum pKa ?
4
% buried
100
Peptide accession
Q9Y297
Residue number A
308
Residue number B
511
Peptide name
F-box/WD repeat-containing protein 1A
Ligandability
Cysteine 308 of F-box/WD repeat-containing protein 1A
Cysteine 511 of F-box/WD repeat-containing protein 1A
6m94 A 262 A 299
A redox-regulated disulphide may form within F-box/WD repeat-containing protein 1A between cysteines 298 and 335 (262 and 299 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
6m94
Structure name
monophosphorylated pser33 b-catenin peptide bound to b-trcp/skp1 complex
Structure deposition date
2018-08-22
Thiol separation (Å)
8
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
54
Peptide accession
Q9Y297
Residue number A
298
Residue number B
335
Peptide name
F-box/WD repeat-containing protein 1A
Ligandability
Cysteine 298 of F-box/WD repeat-containing protein 1A
Cysteine 335 of F-box/WD repeat-containing protein 1A
6ttu T 308 T 471
A redox-regulated disulphide may form within F-box/WD repeat-containing protein 1A between cysteines 308 and 471. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
6ttu
Structure name
ubiquitin ligation to substrate by a cullin-ring e3 ligase at 3
Structure deposition date
2019-12-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
89
Minimum pKa ?
4
% buried
100
Peptide accession
Q9Y297
Residue number A
308
Residue number B
471
Peptide name
F-box/WD repeat-containing protein 1A
Ligandability
Cysteine 308 of F-box/WD repeat-containing protein 1A
Cysteine 471 of F-box/WD repeat-containing protein 1A
1p22 A 435 A 475
A redox-regulated disulphide may form within F-box/WD repeat-containing protein 1A between cysteines 471 and 511 (435 and 475 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
1p22
Structure name
structure of a beta-trcp1-skp1-beta-catenin complex: destruction motif binding and lysine specificity on the scfbeta-trcp1 ubiquitin ligase
Structure deposition date
2003-04-14
Thiol separation (Å)
6
Half-sphere exposure sum ?
102
Minimum pKa ?
12
% buried
100
Peptide accession
Q9Y297
Residue number A
471
Residue number B
511
Peptide name
F-box/WD repeat-containing protein 1A
Ligandability
Cysteine 471 of F-box/WD repeat-containing protein 1A
Cysteine 511 of F-box/WD repeat-containing protein 1A
6m94 A 272 A 312
A redox-regulated disulphide may form within F-box/WD repeat-containing protein 1A between cysteines 308 and 348 (272 and 312 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
6m94
Structure name
monophosphorylated pser33 b-catenin peptide bound to b-trcp/skp1 complex
Structure deposition date
2018-08-22
Thiol separation (Å)
6
Half-sphere exposure sum ?
99
Minimum pKa ?
12
% buried
100
Peptide accession
Q9Y297
Residue number A
308
Residue number B
348
Peptide name
F-box/WD repeat-containing protein 1A
Ligandability
Cysteine 308 of F-box/WD repeat-containing protein 1A
Cysteine 348 of F-box/WD repeat-containing protein 1A
6ttu T 348 T 511
A redox-regulated disulphide may form within F-box/WD repeat-containing protein 1A between cysteines 348 and 511. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
6ttu
Structure name
ubiquitin ligation to substrate by a cullin-ring e3 ligase at 3
Structure deposition date
2019-12-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
93
Minimum pKa ?
5
% buried
100
Peptide accession
Q9Y297
Residue number A
348
Residue number B
511
Peptide name
F-box/WD repeat-containing protein 1A
Ligandability
Cysteine 348 of F-box/WD repeat-containing protein 1A
Cysteine 511 of F-box/WD repeat-containing protein 1A
6m91 A 312 A 363
A redox-regulated disulphide may form within F-box/WD repeat-containing protein 1A between cysteines 348 and 399 (312 and 363 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
6m91
Structure name
monophosphorylated pser33 b-catenin peptide, b-trcp/skp1, nrx-103094 ternary complex
Structure deposition date
2018-08-22
Thiol separation (Å)
7
Half-sphere exposure sum ?
102
Minimum pKa ?
13
% buried
100
Peptide accession
Q9Y297
Residue number A
348
Residue number B
399
Peptide name
F-box/WD repeat-containing protein 1A
Ligandability
Cysteine 348 of F-box/WD repeat-containing protein 1A
Cysteine 399 of F-box/WD repeat-containing protein 1A
6ttu T 348 T 471
A redox-regulated disulphide may form within F-box/WD repeat-containing protein 1A between cysteines 348 and 471. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
20
PDB code
6ttu
Structure name
ubiquitin ligation to substrate by a cullin-ring e3 ligase at 3
Structure deposition date
2019-12-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
91
Minimum pKa ?
14
% buried
100
Peptide accession
Q9Y297
Residue number A
348
Residue number B
471
Peptide name
F-box/WD repeat-containing protein 1A
Ligandability
Cysteine 348 of F-box/WD repeat-containing protein 1A
Cysteine 471 of F-box/WD repeat-containing protein 1A
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