ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Nuclease EXOG, mitochondrial

Intramolecular
Cysteine 294 and cysteine 299
Cysteine 182 and cysteine 299
A redox-regulated disulphide may form within Nuclease EXOG, mitochondrial between cysteines 294 and 299.

Details

Redox score ?
78
PDB code
7r6v
Structure name
human exog complexed with drp-containing dna
Structure deposition date
2021-06-23
Thiol separation (Å)
3
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
51
Peptide accession
Q9Y2C4
Residue number A
294
Residue number B
299
Peptide name
Nuclease EXOG, mitochondrial

Ligandability

Cysteine 294 of Nuclease EXOG, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 299 of Nuclease EXOG, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Nuclease EXOG, mitochondrial between cysteines 182 and 299. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
6iid
Structure name
human exog-h140a in complex with rna-dna chimeric duplex
Structure deposition date
2018-10-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
nan
Peptide accession
Q9Y2C4
Residue number A
182
Residue number B
299
Peptide name
Nuclease EXOG, mitochondrial

Ligandability

Cysteine 182 of Nuclease EXOG, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 299 of Nuclease EXOG, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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