ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Toll-like receptor 6

Intermolecular
Cysteine 712 and cysteine 712
Intramolecular
Cysteine 672 and cysteine 691
A redox-regulated disulphide may form between two units of Toll-like receptor 6 at cysteines 712 and 712.

Details

Redox score ?
80
PDB code
4om7
Structure name
crystal structure of tir domain of tlr6
Structure deposition date
2014-01-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide A name
Toll-like receptor 6
Peptide B name
Toll-like receptor 6
Peptide A accession
Q9Y2C9
Peptide B accession
Q9Y2C9
Peptide A residue number
712
Peptide B residue number
712

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Toll-like receptor 6 between cysteines 672 and 691.

Details

Redox score ?
84
PDB code
4om7
Structure name
crystal structure of tir domain of tlr6
Structure deposition date
2014-01-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y2C9
Residue number A
672
Residue number B
691
Peptide name
Toll-like receptor 6

Ligandability

Cysteine 672 of Toll-like receptor 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 691 of Toll-like receptor 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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