ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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GDP-fucose protein O-fucosyltransferase 2

Intramolecular
Cysteine 161 and cysteine 192
Cysteine 412 and cysteine 419
A redox-regulated disulphide may form within GDP-fucose protein O-fucosyltransferase 2 between cysteines 161 and 192.

Details

Redox score ?
85
PDB code
4ap6
Structure name
crystal structure of human pofut2 e54a mutant in complex with gdp- fucose
Structure deposition date
2012-03-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y2G5
Residue number A
161
Residue number B
192
Peptide name
GDP-fucose protein O-fucosyltransferase 2

Ligandability

Cysteine 161 of GDP-fucose protein O-fucosyltransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 192 of GDP-fucose protein O-fucosyltransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDP-fucose protein O-fucosyltransferase 2 between cysteines 412 and 419.

Details

Redox score ?
85
PDB code
4ap6
Structure name
crystal structure of human pofut2 e54a mutant in complex with gdp- fucose
Structure deposition date
2012-03-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y2G5
Residue number A
412
Residue number B
419
Peptide name
GDP-fucose protein O-fucosyltransferase 2

Ligandability

Cysteine 412 of GDP-fucose protein O-fucosyltransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 419 of GDP-fucose protein O-fucosyltransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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