ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Fibronectin type-III domain-containing protein 3A

Intramolecular
Cysteine 827 and cysteine 846
Cysteine 769 and cysteine 846
Cysteine 806 and cysteine 808
Cysteine 418 and cysteine 420
Cysteine 769 and cysteine 774
Cysteine 769 and cysteine 827
Cysteine 420 and cysteine 439
Cysteine 806 and cysteine 827
A redox-regulated disulphide may form within Fibronectin type-III domain-containing protein 3A between cysteines 827 and 846 (76 and 95 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
1x4x
Structure name
solution structure of the 6th fibronectin type iii domain from human fibronectin type iii domain containing protein 3
Structure deposition date
2005-05-15
Thiol separation (Å)
7
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
54
Peptide accession
Q9Y2H6
Residue number A
827
Residue number B
846
Peptide name
Fibronectin type-III domain-containing protein 3A

Ligandability

Cysteine 827 of Fibronectin type-III domain-containing protein 3A

Cysteine 846 of Fibronectin type-III domain-containing protein 3A

A redox-regulated disulphide may form within Fibronectin type-III domain-containing protein 3A between cysteines 769 and 846 (18 and 95 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
1x4x
Structure name
solution structure of the 6th fibronectin type iii domain from human fibronectin type iii domain containing protein 3
Structure deposition date
2005-05-15
Thiol separation (Å)
8
Half-sphere exposure sum ?
58
Minimum pKa ?
9
% buried
20
Peptide accession
Q9Y2H6
Residue number A
769
Residue number B
846
Peptide name
Fibronectin type-III domain-containing protein 3A

Ligandability

Cysteine 769 of Fibronectin type-III domain-containing protein 3A

Cysteine 846 of Fibronectin type-III domain-containing protein 3A

A redox-regulated disulphide may form within Fibronectin type-III domain-containing protein 3A between cysteines 806 and 808 (55 and 57 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
1x4x
Structure name
solution structure of the 6th fibronectin type iii domain from human fibronectin type iii domain containing protein 3
Structure deposition date
2005-05-15
Thiol separation (Å)
8
Half-sphere exposure sum ?
43
Minimum pKa ?
9
% buried
18
Peptide accession
Q9Y2H6
Residue number A
806
Residue number B
808
Peptide name
Fibronectin type-III domain-containing protein 3A

Ligandability

Cysteine 806 of Fibronectin type-III domain-containing protein 3A

Cysteine 808 of Fibronectin type-III domain-containing protein 3A

A redox-regulated disulphide may form within Fibronectin type-III domain-containing protein 3A between cysteines 418 and 420 (65 and 67 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
1x3d
Structure name
solution structure of the fibronectin type-iii domain of human fibronectin type-iii domain containing protein 3a
Structure deposition date
2005-05-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
44
Minimum pKa ?
10
% buried
28
Peptide accession
Q9Y2H6
Residue number A
418
Residue number B
420
Peptide name
Fibronectin type-III domain-containing protein 3A

Ligandability

Cysteine 418 of Fibronectin type-III domain-containing protein 3A

Cysteine 420 of Fibronectin type-III domain-containing protein 3A

A redox-regulated disulphide may form within Fibronectin type-III domain-containing protein 3A between cysteines 769 and 774 (18 and 23 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
1x4x
Structure name
solution structure of the 6th fibronectin type iii domain from human fibronectin type iii domain containing protein 3
Structure deposition date
2005-05-15
Thiol separation (Å)
10
Half-sphere exposure sum ?
56
Minimum pKa ?
9
% buried
0
Peptide accession
Q9Y2H6
Residue number A
769
Residue number B
774
Peptide name
Fibronectin type-III domain-containing protein 3A

Ligandability

Cysteine 769 of Fibronectin type-III domain-containing protein 3A

Cysteine 774 of Fibronectin type-III domain-containing protein 3A

A redox-regulated disulphide may form within Fibronectin type-III domain-containing protein 3A between cysteines 769 and 827 (18 and 76 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
1x4x
Structure name
solution structure of the 6th fibronectin type iii domain from human fibronectin type iii domain containing protein 3
Structure deposition date
2005-05-15
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
9
% buried
34
Peptide accession
Q9Y2H6
Residue number A
769
Residue number B
827
Peptide name
Fibronectin type-III domain-containing protein 3A

Ligandability

Cysteine 769 of Fibronectin type-III domain-containing protein 3A

Cysteine 827 of Fibronectin type-III domain-containing protein 3A

A redox-regulated disulphide may form within Fibronectin type-III domain-containing protein 3A between cysteines 420 and 439 (67 and 86 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
1x3d
Structure name
solution structure of the fibronectin type-iii domain of human fibronectin type-iii domain containing protein 3a
Structure deposition date
2005-05-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
56
Minimum pKa ?
11
% buried
52
Peptide accession
Q9Y2H6
Residue number A
420
Residue number B
439
Peptide name
Fibronectin type-III domain-containing protein 3A

Ligandability

Cysteine 420 of Fibronectin type-III domain-containing protein 3A

Cysteine 439 of Fibronectin type-III domain-containing protein 3A

A redox-regulated disulphide may form within Fibronectin type-III domain-containing protein 3A between cysteines 806 and 827 (55 and 76 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
1x4x
Structure name
solution structure of the 6th fibronectin type iii domain from human fibronectin type iii domain containing protein 3
Structure deposition date
2005-05-15
Thiol separation (Å)
10
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
51
Peptide accession
Q9Y2H6
Residue number A
806
Residue number B
827
Peptide name
Fibronectin type-III domain-containing protein 3A

Ligandability

Cysteine 806 of Fibronectin type-III domain-containing protein 3A

Cysteine 827 of Fibronectin type-III domain-containing protein 3A

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