a tool for identifying drug-targetable redox-active disulphides

Microtubule-associated serine/threonine-protein kinase 1

Intermolecular

Cysteine 1015 and cysteine 1015

A redox-regulated disulphide may form between two units of Microtubule-associated serine/threonine-protein kinase 1 at cysteines 1015 and 1015. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

23

PDB code

Structure name

pdz domain from human microtubule-associated serine/threonine-protein kinase 1

Structure deposition date

2010-11-30

Thiol separation (Å)

10

Half-sphere exposure sum ?

68

Minimum pK_a ?

12

% buried

86

Peptide A name

Microtubule-associated serine/threonine-protein kinase 1

Peptide B name

Microtubule-associated serine/threonine-protein kinase 1

Peptide A accession

Peptide B accession

Peptide A residue number

1015

Peptide B residue number

1015

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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