ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Band 4.1-like protein 3

Intramolecular
Cysteine 112 and cysteine 124
Cysteine 316 and cysteine 380
A redox-regulated disulphide may form within Band 4.1-like protein 3 between cysteines 112 and 124.

Details

Redox score ?
70
PDB code
3bin
Structure name
structure of the dal-1 and tslc1 (372-383) complex
Structure deposition date
2007-11-30
Thiol separation (Å)
5
Half-sphere exposure sum ?
56
Minimum pKa ?
10
% buried
44
Peptide accession
Q9Y2J2
Residue number A
112
Residue number B
124
Peptide name
Band 4

Ligandability

Cysteine 112 of Band 4.1-like protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 124 of Band 4.1-like protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Band 4.1-like protein 3 between cysteines 316 and 380. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
5rzm
Structure name
epb41l3 pandda analysis group deposition -- crystal structure of the ferm domain of human epb41l3 in complex with z2856434815
Structure deposition date
2020-10-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
10
% buried
88
Peptide accession
Q9Y2J2
Residue number A
316
Residue number B
380
Peptide name
Band 4

Ligandability

Cysteine 316 of Band 4.1-like protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 380 of Band 4.1-like protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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