ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Ubiquitin carboxyl-terminal hydrolase 20

Intramolecular
Cysteine 30 and cysteine 33
Cysteine 33 and cysteine 53
Cysteine 8 and cysteine 86
Cysteine 30 and cysteine 53
Cysteine 83 and cysteine 86
Cysteine 8 and cysteine 83
Cysteine 43 and cysteine 48
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 20 between cysteines 30 and 33.

Details

Redox score ?
80
PDB code
6kcz
Structure name
solution structure of the znf-ubp domain of usp20/vdu2
Structure deposition date
2019-06-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
8
% buried
13
Peptide accession
Q9Y2K6
Residue number A
30
Residue number B
33
Peptide name
Ubiquitin carboxyl-terminal hydrolase 20

Ligandability

Cysteine 30 of Ubiquitin carboxyl-terminal hydrolase 20

Cysteine 33 of Ubiquitin carboxyl-terminal hydrolase 20

A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 20 between cysteines 33 and 53.

Details

Redox score ?
78
PDB code
6kcz
Structure name
solution structure of the znf-ubp domain of usp20/vdu2
Structure deposition date
2019-06-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
7
% buried
14
Peptide accession
Q9Y2K6
Residue number A
33
Residue number B
53
Peptide name
Ubiquitin carboxyl-terminal hydrolase 20

Ligandability

Cysteine 33 of Ubiquitin carboxyl-terminal hydrolase 20

Cysteine 53 of Ubiquitin carboxyl-terminal hydrolase 20

A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 20 between cysteines 8 and 86.

Details

Redox score ?
77
PDB code
6kcz
Structure name
solution structure of the znf-ubp domain of usp20/vdu2
Structure deposition date
2019-06-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
9
% buried
18
Peptide accession
Q9Y2K6
Residue number A
8
Residue number B
86
Peptide name
Ubiquitin carboxyl-terminal hydrolase 20

Ligandability

Cysteine 8 of Ubiquitin carboxyl-terminal hydrolase 20

Cysteine 86 of Ubiquitin carboxyl-terminal hydrolase 20

A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 20 between cysteines 30 and 53.

Details

Redox score ?
77
PDB code
6kcz
Structure name
solution structure of the znf-ubp domain of usp20/vdu2
Structure deposition date
2019-06-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
7
% buried
26
Peptide accession
Q9Y2K6
Residue number A
30
Residue number B
53
Peptide name
Ubiquitin carboxyl-terminal hydrolase 20

Ligandability

Cysteine 30 of Ubiquitin carboxyl-terminal hydrolase 20

Cysteine 53 of Ubiquitin carboxyl-terminal hydrolase 20

A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 20 between cysteines 83 and 86.

Details

Redox score ?
76
PDB code
6kcz
Structure name
solution structure of the znf-ubp domain of usp20/vdu2
Structure deposition date
2019-06-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
9
% buried
24
Peptide accession
Q9Y2K6
Residue number A
83
Residue number B
86
Peptide name
Ubiquitin carboxyl-terminal hydrolase 20

Ligandability

Cysteine 83 of Ubiquitin carboxyl-terminal hydrolase 20

Cysteine 86 of Ubiquitin carboxyl-terminal hydrolase 20

A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 20 between cysteines 8 and 83.

Details

Redox score ?
74
PDB code
6kcz
Structure name
solution structure of the znf-ubp domain of usp20/vdu2
Structure deposition date
2019-06-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
9
% buried
34
Peptide accession
Q9Y2K6
Residue number A
8
Residue number B
83
Peptide name
Ubiquitin carboxyl-terminal hydrolase 20

Ligandability

Cysteine 8 of Ubiquitin carboxyl-terminal hydrolase 20

Cysteine 83 of Ubiquitin carboxyl-terminal hydrolase 20

A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 20 between cysteines 43 and 48.

Details

Redox score ?
74
PDB code
6kcz
Structure name
solution structure of the znf-ubp domain of usp20/vdu2
Structure deposition date
2019-06-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
9
% buried
54
Peptide accession
Q9Y2K6
Residue number A
43
Residue number B
48
Peptide name
Ubiquitin carboxyl-terminal hydrolase 20

Ligandability

Cysteine 43 of Ubiquitin carboxyl-terminal hydrolase 20

Cysteine 48 of Ubiquitin carboxyl-terminal hydrolase 20

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