ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Fanconi-associated nuclease 1

Intramolecular
Cysteine 787 and cysteine 812
Cysteine 659 and cysteine 871
Cysteine 659 and cysteine 700
Cysteine 944 and cysteine 954
A redox-regulated disulphide may form within Fanconi-associated nuclease 1 between cysteines 787 and 812. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
4ric
Structure name
fan1 nuclease bound to 5' hydroxyl (dt-dt) single flap dna
Structure deposition date
2014-10-05
Thiol separation (Å)
10
Half-sphere exposure sum ?
42
Minimum pKa ?
9
% buried
13
Peptide accession
Q9Y2M0
Residue number A
787
Residue number B
812
Peptide name
Fanconi-associated nuclease 1

Ligandability

Cysteine 787 of Fanconi-associated nuclease 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 812 of Fanconi-associated nuclease 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fanconi-associated nuclease 1 between cysteines 659 and 871. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
4reb
Structure name
structural insights into 5' flap dna unwinding and incision by the human fan1 dimer
Structure deposition date
2014-09-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y2M0
Residue number A
659
Residue number B
871
Peptide name
Fanconi-associated nuclease 1

Ligandability

Cysteine 659 of Fanconi-associated nuclease 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 871 of Fanconi-associated nuclease 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fanconi-associated nuclease 1 between cysteines 659 and 700. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
4rib
Structure name
fan1 nuclease bound to 5' phosphorylated p(dt) single flap dna
Structure deposition date
2014-10-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
13
% buried
100
Peptide accession
Q9Y2M0
Residue number A
659
Residue number B
700
Peptide name
Fanconi-associated nuclease 1

Ligandability

Cysteine 659 of Fanconi-associated nuclease 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 700 of Fanconi-associated nuclease 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fanconi-associated nuclease 1 between cysteines 944 and 954. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
4rea
Structure name
a nuclease dna complex
Structure deposition date
2014-09-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
76
Minimum pKa ?
13
% buried
90
Peptide accession
Q9Y2M0
Residue number A
944
Residue number B
954
Peptide name
Fanconi-associated nuclease 1

Ligandability

Cysteine 944 of Fanconi-associated nuclease 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 954 of Fanconi-associated nuclease 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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