ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Hypoxia-inducible factor 3-alpha

Intramolecular
Cysteine 189 and cysteine 221
Cysteine 68 and cysteine 216
Cysteine 254 and cysteine 336
A redox-regulated disulphide may form within Hypoxia-inducible factor 3-alpha between cysteines 189 and 221.

Details

Redox score ?
70
PDB code
7v7w
Structure name
crystal structure of the heterodimeric hif-3a:arnt complex with oleoylethanolamide (oea)
Structure deposition date
2021-08-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
9
% buried
100
Peptide accession
Q0VBL6
Residue number A
189
Residue number B
221
Peptide name
Hypoxia-inducible factor 3-alpha

Ligandability

Cysteine 189 of Hypoxia-inducible factor 3-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 221 of Hypoxia-inducible factor 3-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hypoxia-inducible factor 3-alpha between cysteines 68 and 216. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
7v7l
Structure name
crystal structure of the heterodimeric hif-3a:arnt complex
Structure deposition date
2021-08-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
11
% buried
64
Peptide accession
Q0VBL6
Residue number A
68
Residue number B
216
Peptide name
Hypoxia-inducible factor 3-alpha

Ligandability

Cysteine 68 of Hypoxia-inducible factor 3-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 216 of Hypoxia-inducible factor 3-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hypoxia-inducible factor 3-alpha between cysteines 254 and 336. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
4wn5
Structure name
crystal structure of the c-terminal per-arnt-sim (pasb) of human hif- 3alpha9 bound to 18:1-1-monoacylglycerol
Structure deposition date
2014-10-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
12
% buried
88
Peptide accession
Q9Y2N7
Residue number A
254
Residue number B
336
Peptide name
Hypoxia-inducible factor 3-alpha

Ligandability

Cysteine 254 of Hypoxia-inducible factor 3-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 336 of Hypoxia-inducible factor 3-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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